Massive hepatic necrosis with toxic liver syndrome following portal vein ligation.

Right portal vein ligation (PVL) is a safe and widespread procedure to induce controlateral liver hypertrophy for the treatment of bilobar colorectal liver metastases. We report a case of a 60-year-old man treated by both right PVL and ligation of the glissonian branches of segment 4 for colorectal liver metastases surrounding the right and median hepatic veins. After surgery, the patient developed massive hepatic necrosis with secondary pulmonary and renal insufficiency requiring transfer to the intensive care unit. This so-called toxic liver syndrome finally regressed after hemofiltration and positive oxygen therapy. Diagnosis of acute congestion of the ligated lobe was suspected. The mechanism suspected was an increase in arterial inflow secondary to portal vein ligation concomitant with a decrease in venous outflow due to liver metastases encircling the right and median hepatic vein. This is the first documented case of toxic liver syndrome in a non-cirrhotic patient with favorable issue, and a rare complication of PVL.
AuthorsAurélien Dupré, Johan Gagnière, Lucie Tixier, David Da Ines, Sébastien Perbet, Denis Pezet, Emmanuel Buc
JournalWorld journal of gastroenterology (World J Gastroenterol) Vol. 19 Issue 18 Pg. 2826-9 (May 14 2013) ISSN: 2219-2840 [Electronic] China
PMID23687421 (Publication Type: Case Reports, Journal Article)
  • Biopsy
  • Colorectal Neoplasms (pathology)
  • Hemofiltration
  • Humans
  • Ligation
  • Liver Diseases (etiology, pathology, therapy)
  • Liver Neoplasms (radiography, secondary, surgery)
  • Male
  • Middle Aged
  • Multidetector Computed Tomography
  • Necrosis
  • Oxygen Inhalation Therapy
  • Portal Vein (radiography, surgery)
  • Renal Insufficiency (etiology)
  • Respiratory Insufficiency (etiology)
  • Syndrome
  • Treatment Outcome
  • Vascular Surgical Procedures (adverse effects)

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