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Putting the pieces together: necrolytic migratory erythema and the glucagonoma syndrome.

Abstract
Glucagonomas are slow-growing, rare pancreatic neuroendocrine tumors. They may present with paraneoplastic phenomena known together as the "glucagonoma syndrome." A hallmark sign of this syndrome is a rash known as necrolytic migratory erythema (NME). In this paper, the authors describe a patient with NME and other features of the glucagonoma syndrome. The diagnosis of this rare tumor requires an elevated serum glucagon level and imaging confirming a pancreatic tumor. Surgical and medical treatment options are reviewed. When detected early, a glucagonoma is surgically curable. It is therefore imperative that clinicians recognize the glucagonoma syndrome in order to make an accurate diagnosis and refer for treatment.
AuthorsStephanie A C Halvorson, Erin Gilbert, R Samuel Hopkins, Helen Liu, Charles Lopez, Michael Chu, Marie Martin, Brett Sheppard
JournalJournal of general internal medicine (J Gen Intern Med) Vol. 28 Issue 11 Pg. 1525-9 (Nov 2013) ISSN: 1525-1497 [Electronic] United States
PMID23681843 (Publication Type: Case Reports, Journal Article)
Topics
  • Female
  • Glucagonoma (blood, complications, diagnosis)
  • Humans
  • Middle Aged
  • Necrolytic Migratory Erythema (blood, complications, diagnosis)
  • Pancreatic Neoplasms (blood, complications, diagnosis)

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