Protective effect of lawsone on L-Arginine induced acute pancreatitis in rats.

Abstract	The efficacy of lawsone against L-arginine induced acute pancreatitis was determined at 24 h by determination of serum levels of amylase, lipase and proinflammatory cytokines [tumor necrosis factor (TNF)-alpha, C-reactive proteins and interleukin (IL)], pancreatic myeloperoxidase (MPO) activity, lipid peroxidation (thiobarbituric acid reactive substances (TBARS)], nitrate/nitrite levels, and the wet weight/body weight ratio. Lawsone and methylprednisolone treatments significantly attenuated the L-arginine- induced increases in pancreatic wet weight/body weight ratio, and decreased the serum levels of amylase and lipase, and TNF-alpha and IL-6 and significantly lowered pancreatic levels of MPO, TBARS, and nitrate/nitrite. The histoimmunological findings further proved the amelioration of pancreatic injury by lawsone and further proved anti-inflammatory and antioxidant agent property of lawsone.
Authors	Sandeep Biradar, B Veeresh
Journal	Indian journal of experimental biology (Indian J Exp Biol) Vol. 51 Issue 3 Pg. 256-61 (Mar 2013) ISSN: 0019-5189 [Print] India
PMID	23678547 (Publication Type: Journal Article)
Chemical References	Anti-Inflammatory Agents Antioxidants Cytokines Enzyme Inhibitors Interleukin-6 Interleukins Naphthoquinones Thiobarbituric Acid Reactive Substances Tumor Necrosis Factor-alpha C-Reactive Protein Arginine lawsone
Topics	Acute Disease Animals Anti-Inflammatory Agents (pharmacology, therapeutic use) Antioxidants (metabolism) Arginine (adverse effects) C-Reactive Protein (metabolism) Cytokines (metabolism) Enzyme Inhibitors (pharmacology) Interleukin-6 (metabolism) Interleukins (metabolism) Male Naphthoquinones (pharmacology) Neutrophils (metabolism) Oxidative Stress Pancreas (metabolism) Pancreatitis (chemically induced) Rats Rats, Wistar Thiobarbituric Acid Reactive Substances (metabolism) Tumor Necrosis Factor-alpha (metabolism)

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