[Evaluation using QFT-2G/TBGL/LAM in the patients with osteoarticular tuberculosis of post-treatment period].

Abstract

PURPOSE:

To evaluate results of QFT-2G/TBGL/ LAM in patients who had been completed the antituberculosis treatment for osteoarticular tuberculosis with various periods after the completion of the treatment,

MATERIALS AND METHODS:

Fifty-five patients who had been completed the antituberculosis treatment for osteoarticular tuberculosis at least one year after the completion of treatment were evaluated using QFT-2G/TBGL/LAM tests. Forty patients with spinal tuberculosis and 15 patients with articular tuberculosis were included. The patients with the period after the completion of the treatment less than 4 years were classifled as short-term group (33 patients) and those with the period not less than 4 years were classified as mid-long-term group (22 patients). The results of the tests were compared between the two groups.

RESULTS:

The result of QFT-2G test was positive in 60.6% of the patients in short-term group while 45.5% in mid-long-term group (p=0.12). On the other hand, the result of TBGL test was positive in 75.8% of the patients in short-term group whereas 22.7% in mid-long-term group (p=0.0001) and the result of LAM test was positive in 90.9% of the patients in short-term group whereas 63.6% in mid-long-term group (p= 0.01), both of these tests showed significantly low,er positive rate in mid-long-term group. There was no significant difference in the comparisons between patient groups writh/without pulmonary tuberculosis as well as with/without surgical treatment.

CONCLUSION:

The patients with a history of osteoarticular tuberculosis tend to show positive results of QFT-2-G test for a prolonged period, whereas significantly less positive results of TBGL/LAM tests in mid-long-term.

• Authors: Kazutaka Izawa
• Journal: Kekkaku : [Tuberculosis] (Kekkaku) Vol. 88 Issue 3 Pg. 277-81 (Mar 2013) ISSN: 0022-9776 [Print] Japan
• PMID: 23672167 (Publication Type: English Abstract, Journal Article)

Chemical References

• Glycolipids
• Lipopolysaccharides
• lipoarabinomannan

Topics

• Adult
• Aged
• Aged, 80 and over
• Female
• Glycolipids (blood, immunology)
• Humans
• Interferon-gamma Release Tests
• Lipopolysaccharides (blood)
• Male
• Middle Aged
• Mycobacterium tuberculosis (immunology)
• Tuberculosis, Osteoarticular (blood, drug therapy)
• Tuberculosis, Spinal (blood, drug therapy)