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Analyses of the survival time and the influencing factors of chinese patients with prion diseases based on the surveillance data from 2008-2011.

AbstractBACKGROUND:
Prion diseases are kinds of progressive, incurable neurodegenerative disorders. So far, survival time of the patients with these diseases in China is unclear.
METHODS:
Based upon the surveillance data from Chinese Creutzfeldt-Jakob disease (CJD) surveillance network from January 2008 to December 2011, a retrospective follow-up survey was performed. The survival times of Chinese patients with prion diseases and the possible influencing factors were analyzed.
RESULTS:
Median survival time of 121 deceased patients was 7.1 months, while those for sporadic CJD (sCJD), familial CJD (fCJD) and fatal familial insomnia (FFI) cases were 6.1, 3.1 and 8.2 months, respectively. 74.0% of sCJD patients, 100% of fCJD cases and 91.7% FFI cases died within one year. The general socio-demographic factors, abnormalities in clinical examinations, clinical manifestations, and social factors did not significantly influence the survival times of Chinese prion patients.
CONCLUSIONS:
Survival time of Chinese patients with prion diseases was comparable with that of many Western countries, but obviously shorter than that of Japan. Patients with acute onset and rapid progression had significantly short survival times.
AuthorsCao Chen, Ji-Chun Wang, Qi Shi, Wei Zhou, Xiao-Mei Zhang, Jin Zhang, Chan Tian, Chen Gao, Xiao-Ping Dong
JournalPloS one (PLoS One) Vol. 8 Issue 5 Pg. e62553 ( 2013) ISSN: 1932-6203 [Electronic] United States
PMID23671608 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • China (epidemiology)
  • Creutzfeldt-Jakob Syndrome (epidemiology, mortality, pathology)
  • Epidemiological Monitoring
  • Female
  • Health Services Accessibility
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Prion Diseases (epidemiology, mortality, pathology)
  • Socioeconomic Factors
  • Young Adult

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