Abstract | OBJECTIVE: Higher marine-derived n-3 fatty acids (MDn3FAs) intake reduces the risk of sudden cardiac death via antiarrhythmic effects. The article evaluates whether MDn3FAs intake attenuates the increased risk of cardiac death associated with J-point elevation (JPE), characterised by an elevation of QRS-ST junction (J-point) ≥0.1 mV on electrocardiography. DESIGN: A prospective population-based cohort study. SETTING: The National Survey on Circulatory Disorders and the National Nutrition Survey of Japan. PARTICIPANTS: A total of 4348 community-dwelling men (mean age 49.3 years), without cardiovascular diseases at baseline, from randomly selected areas across Japan. MAIN OUTCOME MEASURES: RESULTS: Dietary MDn3FAs intake was assessed using a dietary method to estimate individual intake of household-based weighed food records for 3 days. Cox models were used to calculate HRs and 95% CIs adjusted for possible confounding factors. JPE was present in 340 participants (7.8%). The median daily intake of MDn3FAs was 0.35%kcal (0.92 g/day). The risk of cardiac death was significantly higher in participants with JPE than in those without JPE in the low intake group (<0.35%kcal; adjusted HR 3.51; 95% CI 1.84 to 6.73; p<0.001), but not in the high intake group (≥0.35%kcal; adjusted HR 1.09; 95% CI 0.56 to 2.16; p=0.795). The interaction between dietary MDn3FAs intake and JPE on the risk of cardiac death was statistically significant (p=0.006). CONCLUSIONS: The increased risk of cardiac death associated with JPE may be attenuated by higher dietary MDn3FAs intake.
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Authors | Takashi Hisamatsu, Katsuyuki Miura, Takayoshi Ohkubo, Takashi Yamamoto, Akira Fujiyoshi, Naoko Miyagawa, Aya Kadota, Naoyuki Takashima, Nagako Okuda, Yasuhiro Matsumura, Katsushi Yoshita, Yoshikuni Kita, Yoshitaka Murakami, Yasuyuki Nakamura, Tomonori Okamura, Minoru Horie, Akira Okayama, Hirotsugu Ueshima, NIPPON DATA80 Research Group |
Journal | Heart (British Cardiac Society)
(Heart)
Vol. 99
Issue 14
Pg. 1024-9
(Jul 2013)
ISSN: 1468-201X [Electronic] England |
PMID | 23666393
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aged
- Cardiovascular Diseases
(diet therapy, mortality, physiopathology)
- Death, Sudden, Cardiac
(epidemiology, etiology, prevention & control)
- Electrocardiography
- Fatty Acids, Omega-3
- Feeding Behavior
- Follow-Up Studies
- Forecasting
- Humans
- Japan
(epidemiology)
- Male
- Middle Aged
- Nutrition Surveys
(methods)
- Proportional Hazards Models
- Prospective Studies
- Risk Factors
- Surveys and Questionnaires
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