[Cardiac arrest caused by massive pulmonary embolism during treatment with tranexamic acid].

Abstract

Pulmonary embolism (PE) as the direct cause of cardiac arrest is well known but probably under-diagnosed. Treatment of menorrhagia with antifibrinolytics is a well documented treatment modality and it is considered safe although thromboembolic complications have been reported. We describe a case of a 30-year-old otherwise healthy woman, who had been treated with antifibrinolytics for up to six months prior to the event, presenting with fatal acute, massive PE and cardiac arrest, which was treated with prompt resuscitation including thrombolysis with recombinant tissue plasminogen activator and subsequent return of spontaneous circulation.

• Authors: Mikkel Gybel, Kjeld Kristensen, Natasha Roseva-Nielsen
• Journal: Ugeskrift for laeger (Ugeskr Laeger) Vol. 175 Issue 20 Pg. 1426-7 (May 13 2013) ISSN: 1603-6824 [Electronic] Denmark
• Vernacular Title: Hjertestop forårsaget af massiv lungeemboli under behandling med tranexamsyre.
• PMID: 23663400 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antifibrinolytic Agents
• Fibrinolytic Agents
• Tranexamic Acid
• Tissue Plasminogen Activator

Topics

• Acute Disease
• Adult
• Antifibrinolytic Agents (adverse effects, therapeutic use)
• Cardiopulmonary Resuscitation
• Fatal Outcome
• Female
• Fibrinolytic Agents (therapeutic use)
• Heart Arrest (etiology, therapy)
• Humans
• Menorrhagia (drug therapy)
• Pulmonary Embolism (chemically induced, complications, diagnostic imaging)
• Thrombolytic Therapy
• Tissue Plasminogen Activator (therapeutic use)
• Tomography, X-Ray Computed
• Tranexamic Acid (adverse effects, therapeutic use)