Treatment of canine generalized demodicosis associated with hyperadrenocorticism with spot-on moxidectin and imidacloprid.

Abstract

BACKGROUND:

Canine generalized demodicosis associated with hyperadrenocorticism is often problematic and might be intractable. The aim of this study was to report the efficacy of a weekly application of spot-on moxidectin/imidacloprid in dogs with hyperadrenocorticism and secondary generalized demodicosis.

METHODS:

Dogs with hyperadrenocorticism and secondary generalized demodicosis were included. The condition of hyperadrenocorticism was treated and stabilized with trilostane before and throughout the study period in all dogs.

RESULTS:

Average total live adult mite counts before treatment and after four, eight and 12 weeks of spot-on moxidectin/imidacloprid (2.5/10 mg/kg) applications were 20.1±6.3 (range, 13-33), 0.5±0.7 (range, 0-2; 6/11 were negative), 0.2±0.4 (range, 0-1; 9/11 were negative), 0.2±0.4 (range, 0-1; 9/11 were negative) and 0.1±0.3 (range, 0-1; 10/11 were negative) respectively; this difference was significant (P<0.001). Ten of 11 dogs (90.1%) achieved clinical remission, as demonstrated by the absence of demodectic mites at any life stage at monthly scrapings for eight consecutive weeks, and maintained remission throughout the 12-month follow-up period.

CONCLUSION:

The weekly application of spot-on moxidectin/imidacloprid appeared to be effective and safe against generalized adult onset canine demodicosis associated with hyperadrenocorticism.

• Authors: Hui-Pi Huang, Yu-Hsin Lien
• Journal: Acta veterinaria Scandinavica (Acta Vet Scand) Vol. 55 Pg. 40 (May 10 2013) ISSN: 1751-0147 [Electronic] England
• PMID: 23663380 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Drug Combinations
• Imidazoles
• Insecticides
• Macrolides
• Neonicotinoids
• Nitro Compounds
• imidacloprid
• moxidectin

Topics

• Administration, Topical
• Adrenocortical Hyperfunction (complications, veterinary)
• Animals
• Dog Diseases (drug therapy, parasitology)
• Dogs
• Drug Combinations
• Imidazoles (administration & dosage, therapeutic use)
• Insecticides (administration & dosage, therapeutic use)
• Macrolides (administration & dosage, therapeutic use)
• Mite Infestations (drug therapy, veterinary)
• Neonicotinoids
• Nitro Compounds (administration & dosage, therapeutic use)