Multifocal periostitis as a complication of chronic use of voriconazole in a lung transplant recipient.

Abstract

Fungal infections are common in solid organ transplantation. An increasing number of transplant recipients receive antifungal therapy for prolonged duration owing to invasive fungal infections. Herein, we describe a diagnosis of periostitis as a complication of chronic use of voriconazole in a lung transplant recipient. The patient was diagnosed with probable pulmonary aspergillosis and was treated with oral voriconazole for a total of 9 months. Evidence of multifocal periostitis was observed in the axial and appendicular skeleton. Early recognition of this phenomenon is important to prevent unnecessary tests and procedures. Prompt discontinuation of voriconazole should result in improvement of symptoms.

• Authors: R Tedja, A El-Sherief, T Olbrych, S Gordon
• Journal: Transplant infectious disease : an official journal of the Transplantation Society (Transpl Infect Dis) Vol. 15 Issue 4 Pg. 424-9 (Aug 2013) ISSN: 1399-3062 [Electronic] Denmark
• PMID: 23663268 (Publication Type: Case Reports, Journal Article, Review)
• Copyright: © 2013 John Wiley & Sons A/S.

Chemical References

• Antifungal Agents
• Pyrimidines
• Triazoles
• Voriconazole

Topics

• Aged
• Antifungal Agents (adverse effects, therapeutic use)
• Chemoprevention
• Female
• Humans
• Lung Diseases, Fungal (complications, drug therapy, microbiology)
• Lung Transplantation (adverse effects)
• Male
• Periostitis (complications, diagnosis, drug therapy, microbiology)
• Pulmonary Aspergillosis (complications, drug therapy, microbiology)
• Pyrimidines (adverse effects, therapeutic use)
• Triazoles (adverse effects, therapeutic use)
• Voriconazole