Abstract | BACKGROUND: Allium sativum, the active ingredient in garlic, is known to have a beneficial effect on major cardiovascular risk factors, including dyslipidemia, blood pressure, blood glucose and insulin levels. However, the data on the significance of these effects are inconsistent due to methodological limitations, especially the use of whole garlic cloves which does not allow controlled dosing of the active compound. OBJECTIVES: To study the effects of purified allicin on the cardiovascular system. METHODS: Spontaneously hypertensive rats treated for 6 weeks with a daily dose of 80 mg/kg/day of purified allicin added to their chow were compared to control rats that were fed regular chow. Weight, systolic blood pressure (SBP), triglycerides, cholesterol, insulin and adiponectin were measured at baseline and at the end of the study. RESULTS: CONCLUSIONS:
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Authors | Amitai Elkayam, Edna Peleg, Ehud Grossman, Zehava Shabtay, Yehonatan Sharabi |
Journal | The Israel Medical Association journal : IMAJ
(Isr Med Assoc J)
Vol. 15
Issue 3
Pg. 170-3
(Mar 2013)
ISSN: 1565-1088 [Print] Israel |
PMID | 23662381
(Publication Type: Journal Article)
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Chemical References |
- Adiponectin
- Antioxidants
- Disulfides
- Insulin
- Sulfinic Acids
- Triglycerides
- allicin
- Cholesterol
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Topics |
- Adiponectin
(blood)
- Administration, Oral
- Animals
- Antioxidants
(administration & dosage, adverse effects)
- Blood Pressure
(drug effects)
- Body Weight
(drug effects)
- Cholesterol
(blood)
- Disulfides
- Dose-Response Relationship, Drug
- Drug Monitoring
- Hypertension
(blood, drug therapy)
- Insulin
(blood)
- Male
- Rats
- Rats, Inbred SHR
- Sulfinic Acids
(administration & dosage, adverse effects)
- Treatment Outcome
- Triglycerides
(blood)
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