THE STUDY WAS THE FIRST TIME TO ESTABLISH AND COMPARE TWO RAT MODELS OF TWO COMMON SYNDROMES: Kidney
Yang Deficiency syndrome (KYDS) in
traditional Chinese medicine (TCM) and abnormal savda syndrome (ASS) in traditional Uighur medicine (TUM). Then, we also established and evaluated rat models of combining disease and syndrome models of
asthma with KYDS or ASS. Results showed that usage of the high dose of
corticosterone (CORT) injection or external factors could successfully establish the KYDS or ASS rat models, and the two models had similar changes in
biological characterization, abnormal behaviors, dysfunction of hypothalamic-pituitary-target organ axes (HPTOA), and sympathetic/parasympathetic (S/P) nerve system but varied in different degrees. The rat models of combining disease and syndrome of
asthma with KYDS or ASS had either pathological characteristics of
asthma such as
airway hyperresponsiveness (AHR), airway
inflammation,
airway remodeling, which were more serious than
allergy exposure alone, or the syndrome performance of Kidney
Yang Deficiency in TCM and abnormal savda in TUM. These findings provide a
biological rationale for further investigation of combining disease and syndrome model of
asthma as an effective animal model for exploring
asthma based on the theory of
traditional medicine.