Abstract | RATIONALE:
Schizophrenia is a severe, persistent, and fairly common mental illness. Haloperidol is widely used and is effective against the symptoms of psychosis seen in schizophrenia. Chronic oral haloperidol administration decreased the number of astrocytes in the parietal cortex of macaque monkeys (Konopaske et al., Biol Psych 63:759-765, 2008). Since astrocytes play a key role in glutamate metabolism, chronic haloperidol administration was hypothesized to modulate astrocyte metabolic function and glutamate homeostasis. OBJECTIVES: METHODS: We used ex vivo ¹³C magnetic resonance spectroscopy along with high-performance liquid chromatography after [1-¹³C] glucose and [1,2-¹³C] acetate administration to analyze forebrain tissue from rats administered oral haloperidol for 1 or 6 months. RESULTS: CONCLUSIONS: Chronic haloperidol administration in rats appears to increase forebrain GABA production along with astrocyte metabolic activity. Studies exploring these processes in subjects with schizophrenia should take into account the potential confounding effects of antipsychotic medication treatment.
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Authors | Glenn T Konopaske, Nicolas R Bolo, Alo C Basu, Perry F Renshaw, Joseph T Coyle |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 230
Issue 1
Pg. 57-67
(Nov 2013)
ISSN: 1432-2072 [Electronic] Germany |
PMID | 23660600
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Antipsychotic Agents
- Glutamine
- Glutamic Acid
- gamma-Aminobutyric Acid
- Glucose
- Haloperidol
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Topics |
- Animals
- Antipsychotic Agents
(administration & dosage, pharmacology)
- Astrocytes
(drug effects, metabolism)
- Chromatography, High Pressure Liquid
- Glucose
(administration & dosage, metabolism)
- Glutamic Acid
(metabolism)
- Glutamine
(metabolism)
- Haloperidol
(administration & dosage, pharmacology)
- Homeostasis
- Magnetic Resonance Spectroscopy
- Male
- Prosencephalon
(drug effects, metabolism)
- Rats
- Rats, Sprague-Dawley
- Schizophrenia
(drug therapy, physiopathology)
- Time Factors
- gamma-Aminobutyric Acid
(metabolism)
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