Abstract | BACKGROUND AND OBJECTIVE: MATERIALS AND METHODS: RESULTS: Significantly increased stress markers, cytoplasmic, lysosomal and extracellular matrix-degrading enzymes as well as the pro-inflammatory mediators TNF-α, IL-1β, IL-6 and COX-2 indicated increased cellular damage but significantly reduced oxidative damage and inflammation in crocin pre-treated groups. CONCLUSION: The data clearly suggest that venom-induced oxidative stress and inflammation is also responsible for oxidative burst and cell death in the circulation, which may worsen even after anti-venin therapy. Hence, the current study demands a supportive therapy in addition to anti-venin therapy to neutralize the overlooked issues of snakebite.
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Authors | M Sebastin Santhosh, M Shanmuga Sundaram, K Sunitha, K Kemparaju, K S Girish |
Journal | Inflammation research : official journal of the European Histamine Research Society ... [et al.]
(Inflamm Res)
Vol. 62
Issue 7
Pg. 721-31
(Jul 2013)
ISSN: 1420-908X [Electronic] Switzerland |
PMID | 23657249
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Cytokines
- Reactive Oxygen Species
- Sulfhydryl Compounds
- Viper Venoms
- Carotenoids
- crocin
- L-Lactate Dehydrogenase
- Catalase
- Cyclooxygenase 2
- PTGS2 protein, human
- Superoxide Dismutase
- Alkaline Phosphatase
- Glycoside Hydrolases
- Hyaluronoglucosaminidase
- Glutathione
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Topics |
- Alkaline Phosphatase
(metabolism)
- Antioxidants
(pharmacology)
- Carotenoids
(pharmacology)
- Catalase
(metabolism)
- Cyclooxygenase 2
(metabolism)
- Cytokines
(metabolism)
- Glutathione
(metabolism)
- Glycoside Hydrolases
(metabolism)
- Humans
- Hyaluronoglucosaminidase
(metabolism)
- L-Lactate Dehydrogenase
(metabolism)
- Oxidative Stress
- Reactive Oxygen Species
(metabolism)
- Serum
(metabolism)
- Snake Bites
- Sulfhydryl Compounds
(metabolism)
- Superoxide Dismutase
(metabolism)
- Viper Venoms
(pharmacology)
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