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Acceleration of conduction within an accessory pathway with propafenone.

Abstract
We describe a case of dangerous acceleration of conduction through an accessory pathway produced by the Class IC agent propafenone during routine electrophysiological study of a patient with Wolff-Parkinson-White syndrome. This pro-arrhythmic effect has not previously been described with this drug. Propafenone is now being more widely used since the publication of the preliminary results of the CAST Study in the U.S.A.
AuthorsA N Sulke, P Holt, G E Sowton
JournalInternational journal of cardiology (Int J Cardiol) Vol. 28 Issue 1 Pg. 105-7 (Jul 1990) ISSN: 0167-5273 [Print] Netherlands
PMID2365521 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Propafenone
Topics
  • Adult
  • Atrial Fibrillation (chemically induced)
  • Atrial Flutter (chemically induced)
  • Cardiac Pacing, Artificial
  • Electrocardiography
  • Electrophysiology
  • Female
  • Heart Conduction System (drug effects)
  • Humans
  • Propafenone (adverse effects)
  • Wolff-Parkinson-White Syndrome (diagnosis)

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