Abstract | OBJECTIVE: STUDY DESIGN: Time-mated Merino ewes with singleton fetuses received saline alone, IA LPS alone, maternal betamethasone before LPS, or betamethasone after LPS. We assessed inflammatory markers in the chorioamnion and the amniotic fluid. RESULTS: Inflammatory cell infiltration, expression of myeloperoxidase, serum amyloid A3 ( acute phase reactant) in the chorioamnion, and levels of interleukin (IL)-8 in the amniotic fluid increased 7 days after LPS exposure. Betamethasone prior to LPS decreased infiltration of the inflammatory cells, CD3+ T cells, and decreased the levels of IL-1β and IL-8 in the amniotic fluid. CONCLUSIONS:
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Authors | Katherine B Wolfe, Candice C Snyder, Tate Gisslen, Matthew W Kemp, John P Newnham, Boris W Kramer, Alan H Jobe, Suhas Kallapur |
Journal | Reproductive sciences (Thousand Oaks, Calif.)
(Reprod Sci)
Vol. 20
Issue 12
Pg. 1447-54
(Dec 2013)
ISSN: 1933-7205 [Electronic] United States |
PMID | 23653388
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Anti-Inflammatory Agents
- CD3 Complex
- Cytokines
- Glucocorticoids
- Inflammation Mediators
- Lipopolysaccharides
- RNA, Messenger
- Serum Amyloid A Protein
- lipopolysaccharide, E coli O55-B5
- Betamethasone
- Peroxidase
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Topics |
- Amnion
(drug effects, immunology, metabolism)
- Amniotic Fluid
(immunology, metabolism)
- Animals
- Anti-Inflammatory Agents
(administration & dosage)
- Betamethasone
(administration & dosage)
- CD3 Complex
(metabolism)
- Chorioamnionitis
(chemically induced, drug therapy, genetics, immunology, metabolism)
- Cytokines
(genetics, metabolism)
- Disease Models, Animal
- Drug Administration Schedule
- Female
- Glucocorticoids
(administration & dosage)
- Inflammation Mediators
(metabolism)
- Lipopolysaccharides
- Maternal-Fetal Exchange
- Peroxidase
(metabolism)
- Pregnancy
- RNA, Messenger
(metabolism)
- Serum Amyloid A Protein
(genetics, metabolism)
- Sheep
- T-Lymphocytes
(drug effects, immunology, metabolism)
- Time Factors
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