Abstract |
We investigated the effects of bisphenol A (BPA), an environmental endocrine-disrupting chemical, on spontaneous motor activity in adult male rats. The rats were implanted intraperitoneally with mini-osmotic pumps containing either BPA (50 μg/kg body weight per day) in sesame oil (BPA-treated group) or sesame oil only (vehicle-treated group). Spontaneous motor activity during a 24-h period was measured over 5 days from day 9 to day 13 after implantation using an animal movement analysis system. Spontaneous motor activity during the last 2 h of the dark phase and during the first 1-h of the light phase was increased in the BPA-treated group. Total spontaneous motor activity during the 12-h light phase, but not the 12-h dark phase, was higher in the BPA-treated group than in the vehicle-treated group. These findings suggest that BPA may induce hyperactivity in adult male rats during the 12-h light phase, especially during the 2 h immediately preceding sleep-onset and 1 h immediately following sleep-onset.
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Authors | Kazuo Nojima, Tomoyo Takata, Hiroshi Masuno |
Journal | The journal of physiological sciences : JPS
(J Physiol Sci)
Vol. 63
Issue 4
Pg. 311-5
(Jul 2013)
ISSN: 1880-6562 [Electronic] Japan |
PMID | 23653311
(Publication Type: Journal Article)
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Chemical References |
- Benzhydryl Compounds
- Phenols
- bisphenol A
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Topics |
- Animals
- Benzhydryl Compounds
(pharmacology)
- Darkness
- Hyperkinesis
(chemically induced)
- Light
- Male
- Motor Activity
(drug effects)
- Phenols
(pharmacology)
- Rats
- Sleep
(drug effects)
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