[C-peptide physiological effects].

Abstract

In the recent years there were numerous evidences that C-peptide, which was previously considered as a product of insulin biosynthesis, is one of the key regulators of physiological processes. C-peptide via heterotrimeric G(i/o) protein-coupled receptors activates a wide range of intracellular effector proteins and transcription factors and, thus, controls the inflammatory and neurotrophic processes, pain sensitivity, cognitive function, macro- and microcirculation, glomerular filtration. These effects of C-peptide are mainly expressed in its absolute or relative deficiency occurred in type 1 diabetes mellitus and they are less pronounced when the level of C-peptide is close to normal. Replacement therapy with C-peptide prevents many complications of type 1 diabetes, such as atherosclerosis, diabetic peripheral neuropathy, and nephropathy. C-peptide interacts with the insulin hexamer complexes and induces their dissociation and, as a result, regulates the functional activity of the insulin signaling system. At the same time, C-peptide at the concentrations above physiological may demonstrate pro-inflammatory effects on the endothelial cells and cause atherosclerotic changes in the vessels, which should be considered in the study of pathogenic mechanisms of complications of type 2 diabetes mellitus, where the level of C peptide is increased, as well as in the development of approaches for C-peptide application in clinic. This review is devoted contemporary achievements and unsolved problems in the study of C-peptide, as an important regulator of physiological and biochemical processes.

• Authors: A O Shpakov, O K Granstrem
• Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova (Ross Fiziol Zh Im I M Sechenova) Vol. 99 Issue 2 Pg. 196-211 (Feb 2013) ISSN: 0869-8139 [Print] Russia (Federation)
• PMID: 23650733 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• C-Peptide
• Insulin

Topics

• C-Peptide (metabolism, physiology)
• Cell Communication (physiology)
• Diabetes Mellitus, Type 1 (metabolism, physiopathology)
• Diabetes Mellitus, Type 2 (metabolism, physiopathology)
• Endothelial Cells (metabolism)
• Humans
• Inflammation (metabolism, physiopathology)
• Insulin (metabolism)
• Microcirculation (physiology)
• Pain (metabolism, physiopathology)
• Signal Transduction