Abstract | OBJECTIVE: METHODS: This multicenter, randomized, and case-controlled clinical trial was conducted among 81 consecutive patients meeting the inclusion criteria. The patients were randomized consecutively to receive TCM treatments according to the syndrome patterns in TCM (spleen and kidney Qi and Yin deficiency, and spleen and kidney Qi and Yang deficiency, n=60) or oral losartan therapy (50 mg/day, n=21) in addition to the basic treatments. All the patients were followed up for 24 weeks to observe the clinical effects. RESULTS: The patients in TCM group showed a significantly higher overall response rate (93.33%) than those in losartan group (76.20%, P<0.05). The TCM score in the two groups were all decreased at week 24 as compared with baseline (P<0.01 or P<0.05). The TCM scores in both groups decreased significantly after the treatments as compared with the baseline scores (P<0.05). After a 8-week-long treatment, Scr, eGFR and Cys-C, U-Pro/24 h, and MA/Cr all decreased significantly in TCM group (P<0.05) but showed no significant changes in losartan group (P>0.05). CONCLUSION:
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Authors | Dong Wang, Tongru Wu, Tingting Xie, Wen Peng, Yi Wang, Min Yuan, Xiuhua Mi, Yueping Bi, Liqun He |
Journal | Nan fang yi ke da xue xue bao = Journal of Southern Medical University
(Nan Fang Yi Ke Da Xue Xue Bao)
Vol. 33
Issue 4
Pg. 502-6
(Apr 2013)
ISSN: 1673-4254 [Print] China |
PMID | 23644107
(Publication Type: English Abstract, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drugs, Chinese Herbal
- Losartan
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Topics |
- Adult
- Aged
- Drugs, Chinese Herbal
(therapeutic use)
- Female
- Humans
- Losartan
(therapeutic use)
- Male
- Medicine, Chinese Traditional
(methods)
- Middle Aged
- Phytotherapy
- Prospective Studies
- Proteinuria
(drug therapy, etiology)
- Renal Insufficiency, Chronic
(complications, drug therapy)
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