Abstract | OBJECTIVES: While chronic obesity is associated with alterations in circulating glycerolipids, sphingolipids and plasmalogens, the effects of short-term overfeeding in humans are unclear. DESIGN AND METHODS: Healthy individuals (n = 40) were overfed by 1,250 kcal day(-1) for 28 days. Insulin sensitivity (hyperinsulinemic-euglycemic clamp), abdominal fat distribution and serum lipidomics (mass spectrometry) were assessed. RESULTS: CONCLUSIONS: Overfeeding led to weight gain and changes in the serum lipid profile. Increases in ceramides were noted, which left unchecked may promote systemic insulin resistance. Uniform increases were observed in plasmalogens and their precursors. Because plasmalogens are powerful antioxidants, this may be an appropriate response against increased oxidative stress generated by over-nutrition. The metabolic consequences of changes in concentrations of many circulating lipid species with overfeeding require further study. Copyright © 2013 The Obesity Society.
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Authors | Leonie K Heilbronn, Adelle C F Coster, Lesley V Campbell, Jerry R Greenfield, Kylie Lange, Michael J Christopher, Peter J Meikle, Dorit Samocha-Bonet |
Journal | Obesity (Silver Spring, Md.)
(Obesity (Silver Spring))
Vol. 21
Issue 12
Pg. E649-59
(Dec 2013)
ISSN: 1930-739X [Electronic] United States |
PMID | 23640727
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 The Obesity Society. |
Chemical References |
- Biomarkers
- Ceramides
- Cholesterol, HDL
- Cholesterol, LDL
- Diglycerides
- F2-Isoprostanes
- Fatty Acids, Nonesterified
- Insulin
- Plasmalogens
- Triglycerides
- C-Reactive Protein
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Topics |
- Adult
- Biomarkers
(blood)
- C-Reactive Protein
(metabolism)
- Ceramides
(blood)
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Diet
- Diglycerides
(blood)
- Energy Intake
- F2-Isoprostanes
(urine)
- Fatty Acids, Nonesterified
(blood)
- Female
- Healthy Volunteers
- Humans
- Insulin
(blood)
- Insulin Resistance
- Male
- Motor Activity
- Overnutrition
(blood)
- Plasmalogens
(blood)
- Triglycerides
(blood)
- Weight Gain
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