Abstract | OBJECTIVE: METHODS: Using immunohistochemistry, we analyzed 60 breast cancers for the levels of annexin A3 and investigated the correlation of its expression change with patient's survival via Kaplan-Meier survival analysis. Furthermore, via knockdown of Annexin A3 expression in breast cancer cells with special siRNA, the role of Annexin A3 in the proliferation and apoptosis of breast cancer cells was examined. RESULTS: CONCLUSION: Our findings indicated that Annexin A3 might be a novel and potential prognostic marker for patients with breast cancer and be involved in regulating apoptosis by affecting Bcl-2/Bax balance.
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Authors | Chao Zeng, Zunfu Ke, Yulan Song, Yunhong Yao, Xinrong Hu, Miao Zhang, Hongmei Li, Jinbao Yin |
Journal | Experimental and molecular pathology
(Exp Mol Pathol)
Vol. 95
Issue 1
Pg. 23-31
(Aug 2013)
ISSN: 1096-0945 [Electronic] Netherlands |
PMID | 23631820
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 Elsevier Inc. All rights reserved. |
Chemical References |
- BAX protein, human
- Biomarkers, Tumor
- Proto-Oncogene Proteins c-bcl-2
- RNA, Small Interfering
- bcl-2-Associated X Protein
- Annexin A3
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Topics |
- Adult
- Aged
- Annexin A3
(genetics, metabolism)
- Apoptosis
(genetics)
- Biomarkers, Tumor
(metabolism)
- Breast Neoplasms
(metabolism, mortality, pathology)
- Cell Line, Tumor
- Female
- Gene Knockdown Techniques
- Humans
- Kaplan-Meier Estimate
- Lymph Nodes
(pathology)
- Lymphatic Metastasis
(pathology)
- Middle Aged
- Prognosis
- Proto-Oncogene Proteins c-bcl-2
(metabolism)
- RNA, Small Interfering
- bcl-2-Associated X Protein
(metabolism)
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