Abstract | INTRODUCTION: METHODS: Antibody findings, thymic histology, and onset age were reviewed for 1141 patients with MG. PPV and NPV of these antibodies for thymoma were determined. RESULTS: The PPV of AChR binding antibodies plus StrAbs was highest (50.0%) with onset before the age of 40 years. The PPV of all antibodies was low (<9%) after age 40. Higher StrAb levels did not increase the PPV. The NPV of AChR binding antibodies was high (99.7%) for all ages. CONCLUSIONS: Patients without AChR binding antibody are not likely to have a thymoma. StrAbs and AChR binding antibodies are not diagnostic for thymoma, but in early-onset MG their presence should raise the clinical suspicion for thymoma.
|
Authors | Emily Choi Decroos, Lisa D Hobson-Webb, Vern C Juel, Janice M Massey, Donald B Sanders |
Journal | Muscle & nerve
(Muscle Nerve)
Vol. 49
Issue 1
Pg. 30-4
(Jan 2014)
ISSN: 1097-4598 [Electronic] United States |
PMID | 23625360
(Publication Type: Comparative Study, Journal Article)
|
Copyright | Copyright © 2013 Wiley Periodicals, Inc. |
Chemical References |
- Antibodies
- Autoantibodies
- Biomarkers
- Receptors, Cholinergic
- myasthenia gravis anti-skeletal muscle antibody
|
Topics |
- Adolescent
- Adult
- Age Factors
- Age of Onset
- Aged
- Aged, 80 and over
- Antibodies
(blood, immunology)
- Autoantibodies
(blood)
- Biomarkers
(blood)
- Child
- Child, Preschool
- Comorbidity
- Female
- Humans
- Infant
- Infant, Newborn
- Male
- Middle Aged
- Muscle, Striated
(immunology)
- Myasthenia Gravis
(epidemiology)
- Receptors, Cholinergic
(immunology)
- Retrospective Studies
- Thymoma
(diagnosis, epidemiology, immunology)
- Thymus Neoplasms
(diagnosis, epidemiology, immunology)
- Young Adult
|