Scleroderma renal crisis and ovarian hyperstimulation syndrome related to the use of clomiphene in a patient with scleroderma.

Abstract

This paper presented a 28-year-old female with systemic sclerosis who developed scleroderma renal crisis and ovarian hyperstimulation syndrome following clomiphene administration. Urgent therapy including angiotensin-converting enzyme (ACE) inhibitors and supportive care resulted in regression and eventually resolution of all the clinical and laboratory symptoms. Although scleroderma renal crisis is a fatal complication of high-dose corticosteroids, rarely is this seen with the use of ACE inhibitors. This case report aimed to investigate the potential capacity of the selective oestrogen receptor modulator clomiphene to induce scleroderma renal crisis as well as corticosteroids.

• Authors: Senol Kobak, Servet Hacivelioglu, Selen Gungor
• Journal: Reumatologia clinica (Reumatol Clin) 2014 Jan-Feb Vol. 10 Issue 1 Pg. 51-3 ISSN: 1885-1398 [Electronic] Spain
• PMID: 23623920 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2012 Elsevier España, S.L. All rights reserved.

Chemical References

• Selective Estrogen Receptor Modulators
• Clomiphene

Topics

• Acute Kidney Injury (chemically induced, diagnosis, etiology)
• Adult
• Clomiphene (adverse effects)
• Female
• Humans
• Ovarian Hyperstimulation Syndrome (chemically induced, diagnosis, etiology)
• Scleroderma, Systemic (complications)
• Selective Estrogen Receptor Modulators (adverse effects)