Abstract | BACKGROUND AIMS:
Stem cell mobilization and harvesting by peripheral blood leukapheresis in patients with myeloma can alter plasma levels of certain cytokines. In the present study, we investigated the effects of these interventions on a larger group of cytokines. METHODS: Plasma cytokine levels were determined in 15 patients with myeloma who were undergoing peripheral blood stem cell harvesting, and we compared the patients with healthy donors who were undergoing platelet apheresis. RESULTS: CONCLUSIONS: Our results demonstrate that patients with myeloma have an altered cytokine network during stem cell mobilization, and the network is further altered during stem cell harvesting by leukapheresis. These treatment- or procedure-induced alterations involve several mediators known to affect myeloma cell proliferation, migration and survival.
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Authors | Knut Anders Mosevoll, Çiğdem Akalin Akkök, Tor Hervig, Guro K Melve, Øystein Bruserud, Håkon Reikvam |
Journal | Cytotherapy
(Cytotherapy)
Vol. 15
Issue 7
Pg. 850-60
(Jul 2013)
ISSN: 1477-2566 [Electronic] England |
PMID | 23623276
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Antigens, CD34
- Cytokines
- Granulocyte Colony-Stimulating Factor
- Interleukin-4
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Topics |
- Adult
- Antigens, CD34
(blood)
- Blood Component Removal
- Cytokines
(blood)
- Female
- Granulocyte Colony-Stimulating Factor
(metabolism)
- Hematopoietic Stem Cell Mobilization
(methods)
- Humans
- Interleukin-4
(blood)
- Leukapheresis
- Male
- Middle Aged
- Multiple Myeloma
(blood, pathology, therapy)
- Peripheral Blood Stem Cell Transplantation
- Transplantation, Autologous
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