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Induction of labor in intrauterine fetal death with 16-phenoxy-prostaglandin-E2-methylsulfonylamide (sulprostone)--effects on uterine contractility, coagulation and kallikrein-kinin systems.

Abstract
Thirty-two patients with intrauterine fetal death after the 20th week of pregnancy were treated with 1-3 intramuscular injections of 500 mg of 16-phenoxy-PGE2-methylsulfonylamide (sulprostone). Intrauterine pressure records demonstrated onset of contractions within 20 min of injection and all women aborted-delivered after in mean 11 h (4-31 h). No effect on routine hematologic and plasma parameters, kallikrein-kinin and factor XII systems was observed. It is concluded that 16-phenoxy-PGE2-methylsulfonylamide is an effective and safe oxytocic agent for the induction of labor in case of intrauterine fetal death with minimal effects on the coagulation system.
AuthorsT Laudański, A Litorowicz, M Akerlund
JournalGynecologic and obstetric investigation (Gynecol Obstet Invest) Vol. 29 Issue 4 Pg. 269-72 ( 1990) ISSN: 0378-7346 [Print] Switzerland
PMID2361635 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Kinins
  • Oxytocics
  • sulprostone
  • Kallikreins
  • Dinoprostone
Topics
  • Adult
  • Blood Coagulation (drug effects)
  • Dinoprostone (analogs & derivatives, pharmacology)
  • Female
  • Fetal Death
  • Humans
  • Kallikreins (metabolism)
  • Kinins (drug effects)
  • Labor, Induced (methods)
  • Oxytocics
  • Uterine Contraction (drug effects)

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