Abstract |
Thirty-two patients with intrauterine fetal death after the 20th week of pregnancy were treated with 1-3 intramuscular injections of 500 mg of 16-phenoxy-PGE2-methylsulfonylamide ( sulprostone). Intrauterine pressure records demonstrated onset of contractions within 20 min of injection and all women aborted-delivered after in mean 11 h (4-31 h). No effect on routine hematologic and plasma parameters, kallikrein- kinin and factor XII systems was observed. It is concluded that 16-phenoxy-PGE2-methylsulfonylamide is an effective and safe oxytocic agent for the induction of labor in case of intrauterine fetal death with minimal effects on the coagulation system.
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Authors | T Laudański, A Litorowicz, M Akerlund |
Journal | Gynecologic and obstetric investigation
(Gynecol Obstet Invest)
Vol. 29
Issue 4
Pg. 269-72
( 1990)
ISSN: 0378-7346 [Print] Switzerland |
PMID | 2361635
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Kinins
- Oxytocics
- sulprostone
- Kallikreins
- Dinoprostone
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Topics |
- Adult
- Blood Coagulation
(drug effects)
- Dinoprostone
(analogs & derivatives, pharmacology)
- Female
- Fetal Death
- Humans
- Kallikreins
(metabolism)
- Kinins
(drug effects)
- Labor, Induced
(methods)
- Oxytocics
- Uterine Contraction
(drug effects)
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