Retroperitoneal amyloidosis as the presenting manifestation of Waldenstrom's macroglobulinaemia.

Abstract

Retroperitoneal amyloidosis has been described in a few case reports and is typically a secondary manifestation of inflammation or malignancy. We present the case of a 69-year-old man who presented with a large pleural effusion and an incidental retroperitoneal mass in the CT imaging. Further investigation confirmed the diagnosis of amyloid amyloidosis involving the retroperitoneum as well as a concurrent Waldenstrom's macroglobulinaemia. Chemotherapy consistent of drugs active against both the lymphoid and plasma cell components of the disease is the proposed therapy for Waldenstrom's macroglobulinaemia in those patients amenable to receive chemotherapy and can make a difference in the survival.

• Authors: Domingo Franco-Palacios, Maher Tama, Suprotim Samaddar, Jay Yang
• Journal: BMJ case reports (BMJ Case Rep) Vol. 2013 (Apr 23 2013) ISSN: 1757-790X [Electronic] England
• PMID: 23616327 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents

Topics

• Aged
• Amyloidosis (diagnosis, drug therapy)
• Antineoplastic Agents (therapeutic use)
• Biopsy, Needle
• Chromatography, Liquid
• Diagnosis, Differential
• Drug Therapy, Combination
• Humans
• Incidental Findings
• Male
• Pleural Effusion (diagnostic imaging)
• Retroperitoneal Space
• Tandem Mass Spectrometry
• Tomography, X-Ray Computed
• Waldenstrom Macroglobulinemia (diagnosis, drug therapy)