The protective effects of β-cryptoxanthin on inflammatory bone resorption in a mouse experimental model of periodontitis.

Abstract

We examined the effects of β-cryptoxanthin, a typical carotenoid, on inflammatory periodontitis. β-Cryptoxanthin suppressed lipopolysaccharide (LPS)-induced osteoclast formation in co-cultures of bone marrow cells and osteoblasts. In a mouse model of periodontitis, it suppressed bone resorption in the mandibular alveolar bone in vitro and restored alveolar bone loss induced by LPS in vivo. β-Cryptoxanthin might protect against periodontal disease.

• Authors: Chiho Matsumoto, Noriyuki Ashida, Satoshi Yokoyama, Tsukasa Tominari, Michiko Hirata, Kazunori Ogawa, Minoru Sugiura, Masamichi Yano, Masaki Inada, Chisato Miyaura
• Journal: Bioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 77 Issue 4 Pg. 860-2 ( 2013) ISSN: 1347-6947 [Electronic] England
• PMID: 23615426 (Publication Type: Journal Article)

Chemical References

• Cryptoxanthins
• Xanthophylls

Topics

• Animals
• Bone Marrow Cells (cytology, drug effects)
• Bone Resorption (drug therapy)
• Cryptoxanthins
• Disease Models, Animal
• Humans
• Inflammation (drug therapy)
• Mice
• NIH 3T3 Cells
• Osteoblasts (drug effects, pathology)
• Osteoclasts (drug effects, pathology)
• Periodontitis (drug therapy, pathology, physiopathology)
• Xanthophylls (pharmacology, therapeutic use)