Abstract | INTRODUCTION: MATERIALS AND METHODS: We investigated a total of 48 infertile males with a history of unilateral ( n = 30) or bilateral (n = 18) cryptorchidism who had undergone successful orchidopexy in prepuberty, and 20 age-matched fertile and healthy males were collected as controls. ASA in sperm samples was detected by the direct immunobead test, and semen analysis was performed concomitantly. RESULTS: No infertile case satisfied the diagnostic criteria of ASA-mediated infertility set forth by the World Health Organization. Decreases in both sperm concentration and motility accompanied by increases in abnormal morphology were seen in infertile cryptorchids when compared with the healthy controls. CONCLUSIONS: Testicular heat exposure in prepuberty is not a risk factor for ASA production. It is evident that the mechanisms that underlie cryptorchidism-associated infertility do not involve ASA. Poor sperm characteristics in cryptorchids resulting from thermal damage to the testes seem to be responsible for their infertility, even after successful orchidopexy.
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Authors | Huan Jiang, Wei-Jie Zhu |
Journal | Urologia internationalis
(Urol Int)
Vol. 90
Issue 4
Pg. 470-4
( 2013)
ISSN: 1423-0399 [Electronic] Switzerland |
PMID | 23614969
(Publication Type: Journal Article)
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Copyright | Copyright © 2013 S. Karger AG, Basel. |
Chemical References |
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Topics |
- Adult
- Analysis of Variance
- Autoantibodies
(blood)
- Case-Control Studies
- Cryptorchidism
(complications, immunology, surgery)
- Humans
- Infertility, Male
(blood, etiology, immunology)
- Male
- Orchiopexy
- Risk Factors
- Sperm Count
- Sperm Motility
- Spermatozoa
(immunology, pathology)
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