Dye laser photodynamic therapy for Bowen's disease in a patient with epidermodysplasia verruciformis.

Abstract

Epidermodysplasia verruciformis (EV) is a rare heritable skin disease that results in unusual susceptibility to infection with specific types of human papillomavirus (HPV). Here we report a 53-year-old man with EV who developed Bowen's disease on his lower eyelid and the chest. Mutation analysis of EVER1 gene revealed homozygous splice acceptor site mutation (IVS8-2, A > T). In this patient, HPV3, HPV14, and HPV38 had been identified from the skin lesions. The Bowen's skin lesion on the left lower eye-lid was treated by photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA) and pulsed dye laser (PDL). After two rounds of the PDT treatment, the skin lesion disappeared and a skin biopsy confirmed the efficacy of the treatment. This method was simple, less invasive than other treatments, and achieved a satisfactory cosmetic result.

• Authors: Mari Sunohara, Toshiyuki Ozawa, Kuniyuki Morimoto, Teruichi Harada, Masamitsu Ishii, Kazuyoshi Fukai
• Journal: Osaka city medical journal (Osaka City Med J) Vol. 58 Issue 2 Pg. 77-82 (Dec 2012) ISSN: 0030-6096 [Print] Japan
• PMID: 23610850 (Publication Type: Case Reports, Journal Article)

Chemical References

• Membrane Proteins
• Photosensitizing Agents
• TMC6 protein, human
• TMC8 protein, human
• Aminolevulinic Acid

Topics

• Aminolevulinic Acid (therapeutic use)
• Biopsy
• Bowen's Disease (drug therapy, pathology, virology)
• Epidermodysplasia Verruciformis (complications, genetics, virology)
• Eyelid Neoplasms (drug therapy, pathology, virology)
• Humans
• Lasers, Dye
• Male
• Membrane Proteins (genetics)
• Middle Aged
• Mutation
• Photochemotherapy (instrumentation)
• Photosensitizing Agents (therapeutic use)
• Skin Neoplasms (drug therapy, pathology, virology)
• Treatment Outcome