Giant myofibroblastoma of the male breast: a case report and literature review.

Abstract

Myofibroblastomas are soft-tissue neoplasms that are thought to arise from myofibroblasts. They are mostly observed in males 41-85 years of age; however, this lesion also occurs in women. The usual clinical presentation is a unilateral painless lump that is not adherent to overlying or underlying structures. Microscopically, myofibroblastomas can be divided into 5 subtypes: classical, epithelioid, collagenised, cellular, and infiltrative. Mammary ducts and lobules are absent in the typical histological subtypes and the adjacent breast parenchyma may form a pseudocapsule. The majority of myofibroblastomas are immunoreactive for CD34, desmin, smooth muscle actin, and vimentin and are negative for cytokeratin and S-100 protein. We present a case of a giant myofibroblastoma arising in the background of gynecomastia in an adult male.

• Authors: Kamal Kataria, Anurag Srivastava, Lavleen Singh, Vaishali Suri, Rajni Yadav
• Journal: The Malaysian journal of medical sciences : MJMS (Malays J Med Sci) Vol. 19 Issue 3 Pg. 74-6 (Jul 2012) ISSN: 1394-195X [Print] Malaysia
• PMID: 23610552 (Publication Type: Journal Article)