Abstract | BACKGROUND: METHODS: RESULTS: Of five men and eight women patients averaging 36 years old, six were diagnosed with venous malformations, six with cavernous haemangiomas, and one with lymphangioma. Proptosis and eyelid swelling were the most common presenting signs. The mean preoperative lesion volume was 4.4±2.3 cm(3) (range, 1.6-8.8 cm(3)), and the average postoperative volume was 1.5±1.7 cm(3) (range, 0.2-6.6 cm(3)) after a single pingyangmycin injection, the dose of which averaged 4.2 mg (range, 2-6 mg). The mean percentage of volume reduction was 70.0% (range, 24.5-88.3%), whereas proptosis reduction averaged 3.2 mm (range, 0-5.5 mm). The lesion volume and proptosis reductions were both statistically significant (p<0.001, and p=0.001). No adverse local or systemic side effects occurred in any of the patients during follow-up averaging 13.3 months. Histopathology of a cavernous haemangioma that underwent a second injection through a surgical incision, showed a mild chronic inflammatory response, increased numbers of myofibroblasts, loss of vascularity and fibrosis, all consistent with known effects of bleomycin treatment. CONCLUSIONS:
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Authors | Han Yue, Jiang Qian, Victor M Elner, Jie Guo, Yi-Fei Yuan, Rui Zhang, Qin Ge |
Journal | The British journal of ophthalmology
(Br J Ophthalmol)
Vol. 97
Issue 6
Pg. 739-45
(Jun 2013)
ISSN: 1468-2079 [Electronic] England |
PMID | 23603483
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Antibiotics, Antineoplastic
- Bleomycin
- bleomycetin
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Topics |
- Adolescent
- Adult
- Antibiotics, Antineoplastic
(administration & dosage, adverse effects)
- Bleomycin
(administration & dosage, adverse effects, analogs & derivatives)
- Female
- Follow-Up Studies
- Humans
- Image Processing, Computer-Assisted
- Injections, Intralesional
- Male
- Middle Aged
- Orbit
(blood supply, diagnostic imaging)
- Orbital Neoplasms
(diagnostic imaging, drug therapy)
- Tomography, X-Ray Computed
- Treatment Outcome
- Vascular Malformations
(diagnostic imaging, drug therapy)
- Vascular Neoplasms
(diagnostic imaging, drug therapy)
- Young Adult
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