Expression of NFkB1, GADD45A and JNK1 in salivary gland carcinomas of different histotypes.

Abstract	The class of salivary gland tumours is very heterogenous, both in a histopathological and clinical sense. Since they are uncommon lesions, their clinical management is still problematic. Molecular mechanisms underlying the development of these cancer types may be fundamental for the diagnosis, treatment and prognosis of this disease. In this study, the gene expression of nuclear factor-kappa B (NKkB1/p65), c-Jun N-terminal kinase (JNK1) and growth arrest and DNA damage (GADD45A), which all play an important role in inflammatory and cell survival mechanisms, was assessed in benign and malignant neoplasms of the salivary gland. The absolute mRNA content of paraffin embedded samples of salivary gland cancer was determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) using specific primers for NFkB1, GADD45A and JNK1. Expression values (relative to HPRT) were statistically evaluated. Among the detected alterations in gene expression, the only difference reaching statistical significance was in the case of NFkB1 in adenocystic carcinomas (p=0.05). Given the importance of these signalling mechanisms in the biology of tumorigenesis, these results may be implemented in further research and these genes might become targets for innovative diagnostic and therapeutic strategies.
Authors	Gyula Gobel, István Szanyi, Péter Révész, Miklós Bauer, Imre Gerlinger, Árpád Németh, István Ember, Katalin Gocze, Katalin Gombos
Journal	Cancer genomics & proteomics (Cancer Genomics Proteomics) 2013 Mar-Apr Vol. 10 Issue 2 Pg. 81-7 ISSN: 1790-6245 [Electronic] Greece
PMID	23603344 (Publication Type: Journal Article)
Chemical References	Cell Cycle Proteins GADD45A protein, human NF-kappa B p50 Subunit NFKB1 protein, human Nuclear Proteins Mitogen-Activated Protein Kinase 8
Topics	Adult Aged Aged, 80 and over Cell Cycle Proteins (biosynthesis, genetics) DNA Damage Female Gene Expression Humans Male Middle Aged Mitogen-Activated Protein Kinase 8 (biosynthesis, genetics) NF-kappa B p50 Subunit (biosynthesis, genetics) Nuclear Proteins (biosynthesis, genetics) Salivary Gland Neoplasms (genetics, metabolism, pathology) Transfection

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