Abstract | PURPOSE: MATERIALS AND METHODS: A retrospective observational study of 104 patients with ARDS caused by pandemic influenza A/H1N1 infection admitted to 28 intensive care units (ICUs) in Korea was performed. Patients were categorized into 3 groups according to the TV they received: TV less than or equal to 7 mL/kg, TV greater than 7 mL/kg but less than or equal to 9 mL/kg, or TV greater than 9 mL/kg. RESULTS: The mean age was 55.1 years, and 55.8% were male (n = 58). Patients with TV greater than 9 mL/kg showed higher 28-day ICU mortality than the 2 other groups (vs TV < 7 mL/kg, P = .007 and vs 7 mL/kg < TV ≤ 9 mL/kg, P = .004, respectively). Patients with TV less than or equal to 7 mL/kg required ventilators, ICU admissions, and hospitalizations for fewer days than those with TV greater than 7 mL/kg (11.4 vs 6.1 days for 28-day ventilator-free days, 9.7 vs 4.9 days for 28-day ICU-free days, and 5.2 vs 2.4 days for 28-day hospital-free days, respectively). Tidal volume greater than 9 mL/kg (hazard rate, 2.459; P = .003) and Sequential Organ Failure Assessment score (hazard rate, 1.158; P = .014) were significant predictors of 28-day ICU mortality. CONCLUSIONS:
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Authors | Dong Kyu Oh, Myung Goo Lee, Eun Young Choi, Jaemin Lim, Hyun-Kyung Lee, Seok Chan Kim, Chae-Man Lim, Younsuck Koh, Sang-Bum Hong, Korean Society of Critical Care Medicine H1N1 collaborative |
Journal | Journal of critical care
(J Crit Care)
Vol. 28
Issue 4
Pg. 358-64
(Aug 2013)
ISSN: 1557-8615 [Electronic] United States |
PMID | 23602273
(Publication Type: Journal Article)
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Copyright | Copyright © 2013 Elsevier Inc. All rights reserved. |
Topics |
- Chi-Square Distribution
- Female
- Hospital Mortality
- Humans
- Influenza A Virus, H1N1 Subtype
- Influenza, Human
(epidemiology, physiopathology, therapy, virology)
- Intensive Care Units
- Male
- Middle Aged
- Pandemics
- Republic of Korea
(epidemiology)
- Respiration, Artificial
(methods)
- Respiratory Distress Syndrome
(epidemiology, physiopathology, therapy, virology)
- Retrospective Studies
- Risk Factors
- Statistics, Nonparametric
- Survival Rate
- Tidal Volume
- Treatment Outcome
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