Abstract | BACKGROUND: OBJECTIVE: METHODS: RESULTS: CONCLUSION: The glutathione S-transferase P1 Ile105Val polymorphism markedly modifies allergen-provoked airway inflammation in atopic asthmatics in vivo. Modulation of the biochemical milieu in response to allergen provides a mechanistic explanation for regulatory effects of glutathione S-transferase P1 polymorphism on airway pathophysiology, and may guide improvement of future therapeutic methods in human atopic asthmatics. These findings must me confirmed in a larger study population of asthmatics with various ethnicities.
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Authors | A Hoskins, P Wu, S Reiss, R Dworski |
Journal | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
(Clin Exp Allergy)
Vol. 43
Issue 5
Pg. 527-34
(May 2013)
ISSN: 1365-2222 [Electronic] England |
PMID | 23600543
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | © 2013 Blackwell Publishing Ltd. |
Chemical References |
- Allergens
- Inflammation Mediators
- Immunoglobulin E
- Glutathione S-Transferase pi
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Topics |
- Adult
- Allergens
(immunology)
- Asthma
(genetics, immunology, metabolism)
- Bronchial Hyperreactivity
(immunology, metabolism)
- Bronchoalveolar Lavage Fluid
(cytology, immunology)
- Female
- Glutathione S-Transferase pi
(genetics)
- Humans
- Hypersensitivity, Immediate
(genetics, immunology, metabolism)
- Immunoglobulin E
(immunology)
- Inflammation Mediators
(immunology, metabolism)
- Male
- Middle Aged
- Oxidative Stress
- Polymorphism, Genetic
- Young Adult
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