[Role of target controlled infusion of remifentanil for the prevention of etomidate induced myoclonus during general anesthesia].

Abstract

OBJECTIVE:

To explore the preventive effect of etomidate-induced myoclonus by different concentrations of target-controlled infusion of remifentanil.

METHODS:

A total of 120 cases undergoing general anesthesia were randomly divided into 4 groups according to different concentrations of target controlled infusion of remifentanil using plasma target controlled infusion ( Minto model) , in which the target concentration was set as 1 f.Lg/L ( group A) , 2 f.Lg/L ( group B) , 3 f.Lg/L ( group C) , and 4 f.Lg/L ( group D) . Five minutes after the balance of effect compartment, induction with etomidate 0. 3 mglkg was conducted intravenously. The intensity and duration of myoclonus was recorded.

RESULTS:

The incidence of etomidate-induced myoclonus was 70.9%, 33.3%, 26.7%, and 0 in groups A, B, C, and D, respectively. Along with the increase of the remifentanil concentration, the incidence of severe myoclonus gradually reduced, which was significantly lower in group B and C than in group A ( P < 0. 05). When the concentration reached 4 f.Lg/L, bradycardia and apnea appeared.

CONCLUSION:

Myoclonus induced by etomidate under general anesthesia can be prevented by target controlled infusion of remifentanil, with 2-3 f.Lg/L being the optimal concentration.

• Authors: Liang Zou, Hao Yuan, Hai-yan Wang, Zhi-yu Geng, Lei Xu, Li Sun
• Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae (Zhongguo Yi Xue Ke Xue Yuan Xue Bao) Vol. 35 Issue 1 Pg. 112-5 (Feb 2013) ISSN: 1000-503X [Print] China
• PMID: 23599979 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Anesthetics, Intravenous
• Piperidines
• Remifentanil
• Etomidate

Topics

• Adult
• Anesthetics, Intravenous (administration & dosage, adverse effects)
• Etomidate (adverse effects)
• Female
• Humans
• Male
• Middle Aged
• Myoclonus (chemically induced, prevention & control)
• Piperidines (administration & dosage)
• Remifentanil