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H₁ but not H₂ histamine antagonist receptors mediate anxiety-related behaviors and emotional memory deficit in mice subjected to elevated plus-maze testing.

Abstract
This study investigated the role of H₁ and H₂ receptors in anxiety and the retrieval of emotional memory using a Trial 1/Trial 2 (T1/T2) protocol in an elevated plus-maze (EPM). Tests were performed on 2 consecutive days, designated T1 and T2. Before T1, the mice received intraperitoneal injections of saline (SAL), 20 mg/kg zolantidine (ZOL, an H2 receptor antagonist), or 8.0 or 16 mg/kg chlorpheniramine (CPA, an H1 receptor antagonist). After 40 min, they were subjected to the EPM test. In T2 (24 h later), each group was subdivided into two additional groups, and the animals from each group were re-injected with SAL or one of the drugs. In T1, the Student t-test showed no difference between the SAL and ZOL or 8 mg/kg CPA groups with respect to the percentages of open arm entries (%OAE) and open arm time (%OAT). However, administration of CPA at the highest dose of 16 mg/kg decreased %OAE and %OAT, but not locomotor activity, indicating anxiogenic-like behavior. Emotional memory, as revealed by a reduction in open arm exploration between the two trials, was observed in all experimental groups, indicating that ZOL and 8 mg/kg CPA did not affect emotional memory, whereas CPA at the highest dose affected acquisition and consolidation, but not retrieval of memory. Taken together, these results suggest that H₁ receptor, but not H₂, is implicated in anxiety-like behavior and in emotional memory acquisition and consolidation deficits in mice subjected to EPM testing.
AuthorsK R Serafim, M S Kishi, A Canto-de-Souza, R Mattioli
JournalBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas (Braz J Med Biol Res) Vol. 46 Issue 5 Pg. 440-6 (May 2013) ISSN: 1414-431X [Electronic] Brazil
PMID23598647 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Benzothiazoles
  • Histamine H1 Antagonists
  • Histamine H2 Antagonists
  • Phenoxypropanolamines
  • Piperidines
  • Receptors, Histamine H1
  • Chlorpheniramine
  • zolantidine
Topics
  • Animals
  • Anxiety (chemically induced)
  • Benzothiazoles (pharmacology)
  • Chlorpheniramine (pharmacology)
  • Histamine H1 Antagonists (pharmacology)
  • Histamine H2 Antagonists (pharmacology)
  • Male
  • Maze Learning
  • Memory Disorders (chemically induced)
  • Mice
  • Microinjections
  • Phenoxypropanolamines (pharmacology)
  • Piperidines (pharmacology)
  • Receptors, Histamine H1 (drug effects)

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