Abstract | OBJECTIVE: More than 60% of patients worldwide with Creutzfeldt-Jakob disease (CJD) associated with dura mater graft (dCJD) have been diagnosed in Japan. The remarkable frequency of dura mater grafts in Japan may possibly contribute to the elevated incidence of dCJD, but reasons for the disproportionate use of this procedure in Japan remain unclear. We investigated differences between dCJD patients in Japan and those elsewhere to help explain the more frequent use of cadaveric dura mater and the high incidence of dCJD in Japan. METHODS: We obtained data on dCJD patients in Japan from the Japanese national CJD surveillance programme and on dCJD patients in other countries from the extant literature. We compared the demographic, clinical and pathological features of dCJD patients in Japan with those from other countries. RESULTS: CONCLUSIONS: Differences in the medical conditions precipitating dura mater graft may contribute to the frequent use of cadaveric dura mater and the higher incidence of dCJD in Japan.
|
Authors | Tsuyoshi Hamaguchi, Kenji Sakai, Moeko Noguchi-Shinohara, Ichiro Nozaki, Ichiro Takumi, Nobuo Sanjo, Atsuko Sadakane, Yosikazu Nakamura, Tetsuyuki Kitamoto, Nobuhito Saito, Hidehiro Mizusawa, Masahito Yamada |
Journal | Journal of neurology, neurosurgery, and psychiatry
(J Neurol Neurosurg Psychiatry)
Vol. 84
Issue 10
Pg. 1171-5
(Oct 2013)
ISSN: 1468-330X [Electronic] England |
PMID | 23595947
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Topics |
- Adolescent
- Adult
- Cadaver
- Child
- Creutzfeldt-Jakob Syndrome
(epidemiology, transmission)
- Cross-Cultural Comparison
- Cross-Sectional Studies
- Dura Mater
(transplantation, virology)
- Female
- Humans
- Iatrogenic Disease
- Japan
- Male
- Middle Aged
- Population Surveillance
- Risk Factors
|