Abstract | BACKGROUND: METHODS: We evaluated CK7, Cam 5.2 and Ber-Ep4 expression in SCC and EPD. RESULTS: We found significant CK7 and Cam 5.2 positivity in SCCs, particularly in those with a pagetoid pattern. Only one case expressed Ber-Ep4. CONCLUSIONS: We conclude that CK7 and Cam 5.2 expression may occur in SCC. A panel including Ber-Ep4 is advisable for immunohistochemical differentiation of EPD from SCC.
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Authors | Loren E Clarke, Andrea B Conway, Nicole M Warner, Patricia N Barnwell, Jennifer Sceppa, Klaus F Helm |
Journal | Journal of cutaneous pathology
(J Cutan Pathol)
Vol. 40
Issue 7
Pg. 646-50
(Jul 2013)
ISSN: 1600-0560 [Electronic] United States |
PMID | 23590728
(Publication Type: Clinical Trial, Journal Article)
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Copyright | © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Chemical References |
- Biomarkers
- Biomarkers, Tumor
- CAM 5.2 antigen
- Keratin-7
- Neoplasm Proteins
- human epithelial antigen-125
- Keratins
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Topics |
- Biomarkers
- Biomarkers, Tumor
(biosynthesis)
- Carcinoma, Squamous Cell
(metabolism, pathology)
- Female
- Gene Expression Regulation
- Humans
- Keratin-7
(biosynthesis)
- Keratins
(biosynthesis)
- Male
- Neoplasm Proteins
(biosynthesis)
- Skin Neoplasms
(metabolism, pathology)
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