Abstract | BACKGROUND: METHODS: We searched in the Pubmed, Embase, and Wangfang Medicine databases for studies assessing the association between GSTT1 null genotype and gastric cancer risk. The pooled odds ratio (OR) and its 95% confidence interval (95%CI) was calculated to assess the strength of the association. A total of 48 studies with a total of 24,440 individuals were ultimately eligible for meta-analysis. RESULTS: Overall, GSTT1 null genotype was significantly associated with increased risk of gastric cancer (Random-effect OR = 1.23, 95%CI 1.13-1.35, P OR <0.001, I(2) = 45.5%). Significant association was also found in Caucasians, East Asians, and Indians (P Caucasians = 0.010; P East Asians = 0.003; P Indians = 0.017). After adjusting for other confounding variables, GSTT1 null genotype was also significantly associated with increased risk of gastric cancer (Random-effect OR = 1.43, 95%CI 1.20-1.71, P OR <0.001, I(2) = 48.1%). CONCLUSION: The meta-analysis provides strong evidence for the significant association between GSTT1 null genotype and increased risk of gastric cancer.
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Authors | Weiyuan Ma, Le Zhuang, Bo Han, Bo Tang |
Journal | PloS one
(PLoS One)
Vol. 8
Issue 4
Pg. e60833
( 2013)
ISSN: 1932-6203 [Electronic] United States |
PMID | 23585855
(Publication Type: Journal Article, Meta-Analysis)
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Chemical References |
- glutathione S-transferase T1
- Glutathione Transferase
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Topics |
- Asian People
- Case-Control Studies
- Databases, Bibliographic
- Female
- Genetic Predisposition to Disease
- Glutathione Transferase
(deficiency, genetics)
- Humans
- Male
- Odds Ratio
- Polymorphism, Genetic
- Risk
- Stomach Neoplasms
(ethnology, genetics)
- White People
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