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Warfarin-induced calciphylaxis successfully treated with sodium thiosulphate.

Abstract
Calciphylaxis is a rare life-threatening form of skin necrosis. Although traditionally observed in patients with end-stage renal disease and/or hyperparathyroidism, calciphylaxis has also been reported to occur in 'non-traditional' patients with normal renal and parathyroid function. We report a case of warfarin-induced calciphylaxis treated successfully with sodium thiosulphate and discuss the role of Vitamin K2 as a potential therapeutic option in the management of warfarin-induced calciphylaxis.
AuthorsJuber Hafiji, Patrick Deegan, Rebecca Brais, Paul Norris
JournalThe Australasian journal of dermatology (Australas J Dermatol) Vol. 54 Issue 2 Pg. 133-5 (May 2013) ISSN: 1440-0960 [Electronic] Australia
PMID23581997 (Publication Type: Case Reports, Journal Article)
Copyright© 2012 The Authors. Australasian Journal of Dermatology © 2012 The Australasian College of Dermatologists.
Chemical References
  • Anticoagulants
  • Antioxidants
  • Thiosulfates
  • Warfarin
  • sodium thiosulfate
Topics
  • Anticoagulants (adverse effects)
  • Antioxidants (therapeutic use)
  • Calciphylaxis (chemically induced, drug therapy)
  • Drug Eruptions (drug therapy)
  • Humans
  • Male
  • Middle Aged
  • Skin Ulcer (chemically induced, therapy)
  • Thiosulfates (therapeutic use)
  • Warfarin (adverse effects)

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