Abstract |
This study examines the antiobesity effects of fucoidan in an animal model of diet-induced obesity. Mice were fed a standard diet or high-fat diet (HFD) for 5 weeks. After that, the mice were divided into four experimental groups, with 10 mice per group, including a standard diet group, HFD group, HFD containing 1% fucoidan (HFD + FUCO 1%) group and HFD containing 2% fucoidan (HFD + FUCO 2%) group. The fucoidan supplementation group had significantly decreased body-weight gain, food efficiency ratio and relative liver and epididymal fat mass compared with the HFD group. The mice supplemented with fucoidan showed significantly reduced triglyceride, total cholesterol and low-density lipoprotein levels in the plasma. Liver steatosis induced by the HFD improved in the fucoidan-supplemented group. Furthermore, fucoidan affected the down-regulation expression patterns of epididymal adipose tissue genes such as peroxisome proliferator-activated receptor γ, adipose-specific fatty acid binding protein and acetyl CoA carboxylase. Therefore, fucoidan may be considered for use in improving obesity.
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Authors | Mi-Ja Kim, Joseph Jeon, Jin-Sil Lee |
Journal | Phytotherapy research : PTR
(Phytother Res)
Vol. 28
Issue 1
Pg. 137-43
(Jan 2014)
ISSN: 1099-1573 [Electronic] England |
PMID | 23580241
(Publication Type: Journal Article)
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Copyright | Copyright © 2013 John Wiley & Sons, Ltd. |
Chemical References |
- Anti-Obesity Agents
- Fatty Acid-Binding Proteins
- Lipoproteins, LDL
- PPAR gamma
- Polysaccharides
- Triglycerides
- fucoidan
- Cholesterol
- Acetyl-CoA Carboxylase
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Topics |
- Acetyl-CoA Carboxylase
(genetics, metabolism)
- Adipose Tissue
(drug effects, metabolism)
- Animals
- Anti-Obesity Agents
(pharmacology)
- Cholesterol
(blood)
- Diet, High-Fat
(adverse effects)
- Dietary Supplements
- Down-Regulation
(drug effects)
- Epididymis
(drug effects)
- Fatty Acid-Binding Proteins
(genetics, metabolism)
- Lipoproteins, LDL
(blood)
- Liver
(drug effects, pathology)
- Male
- Mice
- Mice, Inbred C57BL
- Obesity
(drug therapy, metabolism)
- PPAR gamma
(genetics, metabolism)
- Polysaccharides
(pharmacology)
- Triglycerides
(blood)
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