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Fucoidan prevents high-fat diet-induced obesity in animals by suppression of fat accumulation.

Abstract
This study examines the antiobesity effects of fucoidan in an animal model of diet-induced obesity. Mice were fed a standard diet or high-fat diet (HFD) for 5 weeks. After that, the mice were divided into four experimental groups, with 10 mice per group, including a standard diet group, HFD group, HFD containing 1% fucoidan (HFD + FUCO 1%) group and HFD containing 2% fucoidan (HFD + FUCO 2%) group. The fucoidan supplementation group had significantly decreased body-weight gain, food efficiency ratio and relative liver and epididymal fat mass compared with the HFD group. The mice supplemented with fucoidan showed significantly reduced triglyceride, total cholesterol and low-density lipoprotein levels in the plasma. Liver steatosis induced by the HFD improved in the fucoidan-supplemented group. Furthermore, fucoidan affected the down-regulation expression patterns of epididymal adipose tissue genes such as peroxisome proliferator-activated receptor γ, adipose-specific fatty acid binding protein and acetyl CoA carboxylase. Therefore, fucoidan may be considered for use in improving obesity.
AuthorsMi-Ja Kim, Joseph Jeon, Jin-Sil Lee
JournalPhytotherapy research : PTR (Phytother Res) Vol. 28 Issue 1 Pg. 137-43 (Jan 2014) ISSN: 1099-1573 [Electronic] England
PMID23580241 (Publication Type: Journal Article)
CopyrightCopyright © 2013 John Wiley & Sons, Ltd.
Chemical References
  • Anti-Obesity Agents
  • Fatty Acid-Binding Proteins
  • Lipoproteins, LDL
  • PPAR gamma
  • Polysaccharides
  • Triglycerides
  • fucoidan
  • Cholesterol
  • Acetyl-CoA Carboxylase
Topics
  • Acetyl-CoA Carboxylase (genetics, metabolism)
  • Adipose Tissue (drug effects, metabolism)
  • Animals
  • Anti-Obesity Agents (pharmacology)
  • Cholesterol (blood)
  • Diet, High-Fat (adverse effects)
  • Dietary Supplements
  • Down-Regulation (drug effects)
  • Epididymis (drug effects)
  • Fatty Acid-Binding Proteins (genetics, metabolism)
  • Lipoproteins, LDL (blood)
  • Liver (drug effects, pathology)
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Obesity (drug therapy, metabolism)
  • PPAR gamma (genetics, metabolism)
  • Polysaccharides (pharmacology)
  • Triglycerides (blood)

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