[Supplemental role of thrombospondin-1 in the diagnosis of prostate cancer].

Abstract

OBJECTIVE:

To employ enzyme-linked immunosorbent assay (ELISA) to measure the serum level of thrombospondin-1 (TSP-1) and analyze its diagnostic value for prostate cancer.

METHODS:

The serum levels of TSP-1 were measured by human TSP-1 ELISA kit in 50 patients with organ-confined prostate cancer (n = 22) and non-organ-confined prostate cancer (n = 28). And the subjects of benign prostatic hyperplasia (BPH, n = 20) and healthy controls (n = 16) were selected.

RESULTS:

The average serum concentration of TSP-1 was (200 ± 49) µg/L in prostate cancer group, (281 ± 53) µg/L in BPH group and (323 ± 56) µg/L in healthy control group. There were significant inter-group differences in the serum levels of TSP-1 (both P < 0.05). The average serum concentration of TSP-1 was (216 ± 34) µg/L in organ-confined prostate cancer (including stages I and II) and (188 ± 49) µg/L in non-organ-confined prostate cancer (including stages III and IV) respectively (P = 0.030). The level of TSP-1 was also correlated with Gleason score (r = -0.32, P = 0.023). However, the relationship between TSP-1 levels and lymph node metastasis remained elusive (P = 0.189). The diagnostic sensitivity and specificity of TSP-1 and prostate specific antigen (PSA) for prostate cancer were 72%, 90% and 64%, 70% respectively (both P < 0.05). The area under the receiver operating characteristic curve (ROC) of TSP-1 and PSA were 0.886 and 0.719 respectively (P = 0.028).

CONCLUSION:

As a relatively ideal predictor of prostate cancer, the serum concentration of TSP-1 can not only distinguish prostate cancer from BPH, but also correlate with tumor stage and Gleason grade.

• Authors: Jian-cheng Lu, Ding-wei Ye, Wen-zhi Li, Li-huan Du, Wei Jin, Xue-qiang Lu, Ji-hong Zhang, Gang Chen
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 93 Issue 4 Pg. 252-5 (Jan 22 2013) ISSN: 0376-2491 [Print] China
• PMID: 23578502 (Publication Type: English Abstract, Journal Article)

Chemical References

• Thrombospondin 1

Topics

• Aged
• Aged, 80 and over
• Case-Control Studies
• Humans
• Male
• Middle Aged
• Prostatic Neoplasms (blood, diagnosis)
• Sensitivity and Specificity
• Thrombospondin 1 (blood)