Silicone sheet containing all-trans retinoic acid and hydroquinone for the treatment of epidermal melanosis.

Although bleaching treatment using all-trans retinoic acid (RA) and hydroquinone (HQ) improves epidermal melanosis, the application of two medications and the irritant dermatitis induced by RA inconvenience patients. To overcome these problems, we developed a silicone sheet containing RA and HQ.
To compare the efficacy of a silicone sheet containing RA and HQ with that of conventional bleaching treatment.
Silicone sheets containing 1% RA and 5% HQ were applied at night during the bleaching phase of 4 weeks, followed by application of sheets containing 5% HQ during the healing phase of 4 weeks. Hemifacial epidermal melanosis, for which the sheets were applied, was compared with a contralateral face which was treated conventionally using RA and HQ. Twenty-four Japanese women who were enrolled in this study and followed up for more than 6 months were analyzed.
RA/HQ sheets improved epidermal melanosis, as did the conventional bleaching method, but irritant dermatitis occurred less in patients treated using silicone sheets.
RA/HQ sheets, which are easily applied to face skin, can improve epidermal melanosis to the same extent as conventional bleaching.
AuthorsShoko Iida, Akihiko Takushima, Norihiko Ohura, Suguru Sato, Masakazu Kurita, Kiyonori Harii
JournalDermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] (Dermatol Surg) Vol. 39 Issue 8 Pg. 1237-42 (Aug 2013) ISSN: 1524-4725 [Electronic] United States
PMID23577722 (Publication Type: Journal Article)
Copyright© 2013 by the American Society for Dermatologic Surgery, Inc. Published by Wiley Periodicals, Inc.
Chemical References
  • Antioxidants
  • Hydroquinones
  • Keratolytic Agents
  • Silicones
  • Skin Lightening Preparations
  • hydroquinone
  • Tretinoin
  • Adult
  • Aged
  • Antioxidants (administration & dosage)
  • Drug Therapy, Combination
  • Female
  • Humans
  • Hydroquinones (administration & dosage)
  • Keratolytic Agents (administration & dosage)
  • Lentigo (drug therapy)
  • Male
  • Melanosis (drug therapy, pathology)
  • Middle Aged
  • Silicones
  • Skin (pathology)
  • Skin Lightening Preparations (administration & dosage)
  • Tretinoin (administration & dosage)

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