Silicone sheet containing all-trans retinoic acid and hydroquinone for the treatment of epidermal melanosis.

Abstract

BACKGROUND:

Although bleaching treatment using all-trans retinoic acid (RA) and hydroquinone (HQ) improves epidermal melanosis, the application of two medications and the irritant dermatitis induced by RA inconvenience patients. To overcome these problems, we developed a silicone sheet containing RA and HQ.

OBJECTIVE:

To compare the efficacy of a silicone sheet containing RA and HQ with that of conventional bleaching treatment.

METHOD:

Silicone sheets containing 1% RA and 5% HQ were applied at night during the bleaching phase of 4 weeks, followed by application of sheets containing 5% HQ during the healing phase of 4 weeks. Hemifacial epidermal melanosis, for which the sheets were applied, was compared with a contralateral face which was treated conventionally using RA and HQ. Twenty-four Japanese women who were enrolled in this study and followed up for more than 6 months were analyzed.

RESULTS:

RA/HQ sheets improved epidermal melanosis, as did the conventional bleaching method, but irritant dermatitis occurred less in patients treated using silicone sheets.

CONCLUSION:

RA/HQ sheets, which are easily applied to face skin, can improve epidermal melanosis to the same extent as conventional bleaching.

• Authors: Shoko Iida, Akihiko Takushima, Norihiko Ohura, Suguru Sato, Masakazu Kurita, Kiyonori Harii
• Journal: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] (Dermatol Surg) Vol. 39 Issue 8 Pg. 1237-42 (Aug 2013) ISSN: 1524-4725 [Electronic] United States
• PMID: 23577722 (Publication Type: Journal Article)
• Copyright: © 2013 by the American Society for Dermatologic Surgery, Inc. Published by Wiley Periodicals, Inc.

Chemical References

• Antioxidants
• Hydroquinones
• Keratolytic Agents
• Silicones
• Skin Lightening Preparations
• Tretinoin
• hydroquinone

Topics

• Adult
• Aged
• Antioxidants (administration & dosage)
• Drug Therapy, Combination
• Female
• Humans
• Hydroquinones (administration & dosage)
• Keratolytic Agents (administration & dosage)
• Lentigo (drug therapy)
• Male
• Melanosis (drug therapy, pathology)
• Middle Aged
• Silicones
• Skin (pathology)
• Skin Lightening Preparations (administration & dosage)
• Tretinoin (administration & dosage)