Interaction of free fatty acids with the erythrocyte membrane as affected by hyperthermia and ionizing radiation.

Abstract

The interference of hyperthermia and ionizing radiation, respectively, with the effects of capric (10:0), lauric (12:0), myristic (14:0), oleic (cis-18:1) and elaidic (trans-18:1) acids on the osmotic resistance of human erythrocytes was investigated. The results are summarized as follows: (A) not only at 37 degrees, but also at 42 degrees and 47 degrees C lauric acid (12:0) represents the minimum chain length for the biphasic behaviour of protecting against hypotonic hemolysis at a certain lower concentration range and hemolysis promotion at subsequent higher concentrations; (B) with increasing temperatures the protecting as well as the hemolytic effects occur at lower concentrations of the fatty acids; (C) the increase of temperature promotes the extent of hemolysis and reduces the extent of protection against hypotonic hemolysis; (D) Gamma-irradiation of erythrocytes selectively affects the concentration of oleic acid at which maximum protection against hypotonic hemolysis occurs, without altering the minimum concentration for 100% hemolysis.

• Authors: M Rybczynska, A Csordas
• Journal: Bioscience reports (Biosci Rep) Vol. 10 Issue 2 Pg. 155-63 (Apr 1990) ISSN: 0144-8463 [Print] England
• PMID: 2357483 (Publication Type: Journal Article)

Chemical References

• Decanoic Acids
• Fatty Acids
• Lauric Acids
• Myristic Acids
• Oleic Acids
• Oleic Acid
• elaidic acid

Topics

• Decanoic Acids (metabolism)
• Erythrocyte Membrane (metabolism, radiation effects)
• Fatty Acids (metabolism)
• Hemolysis
• Humans
• Lauric Acids (metabolism)
• Myristic Acids (metabolism)
• Oleic Acid
• Oleic Acids (metabolism)
• Stereoisomerism
• Temperature