Analgesic, anti-inflammatory and anti-diarrheal activities of ethanolic leaf extract of Typhonium trilobatum L. Schott.

Abstract

OBJECTIVE:

To explore the efficacy of ethanolic leaf extract of Typhonium trilobatum L. Schott in treating diarrhea, pain and inflammation using experimental models.

METHODS:

In the present study, acetic acid-induced writhing, xylene-induced ear edema and castor oil-induced diarrheal model were used to evaluate the analgesic, anti-inflammatory and anti-diarrheal activities, respectively. Acute toxicity test was carried out to fix the safe doses of the plant extract.

RESULTS:

The plant extract demonstrated a significant inhibition of writhing (P<0.01) compared with the control group in acetic acid-induced writhing test in mice. The extract also significantly inhibited the xylene induced ear edema formation (P<0.05). In anti-diarrheal test, the extract significantly decreased the frequency of defecation and increased the mean latent period (P<0.01) in castor oil-induced diarrheal model mice at the doses of 250 and 500 mg/kg body weight.

CONCLUSIONS:

These results suggest that the extract possesses significant analgesic, anti-inflammatory and anti-diarrheal activities that support to the ethnopharmacological uses of this plant.

• Authors: Khadem Ali, Ayesha Ashraf, Nripendra Nath Biswas
• Journal: Asian Pacific journal of tropical biomedicine (Asian Pac J Trop Biomed) Vol. 2 Issue 9 Pg. 722-6 (Sep 2012) ISSN: 2221-1691 [Print] China
• PMID: 23570002 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Analgesics
• Anti-Inflammatory Agents
• Antidiarrheals
• Phytochemicals
• Plant Extracts

Topics

• Analgesics (chemistry, pharmacology)
• Animals
• Anti-Inflammatory Agents (chemistry, pharmacology)
• Antidiarrheals (chemistry, pharmacology)
• Diarrhea (chemically induced, drug therapy)
• Disease Models, Animal
• Edema (chemically induced, drug therapy)
• Female
• Magnoliopsida (chemistry)
• Male
• Mice
• Phytochemicals (chemistry)
• Plant Extracts (chemistry, pharmacology)
• Plant Leaves (chemistry)
• Rats
• Toxicity Tests, Acute