Abstract | OBJECTIVE: METHODS: RESULTS: The mean ± SE labelling index (LI) of CaSR (12.8% ± 1.5%) in nodular hyperplasia was significantly lower than that in normal parathyroid glands (26.8% ± 0.8%), whereas the mean ± SE LI of CaSR in diffuse hyperplasia was similar to that in normal parathyroid glands (23.3% ± 1.8%). The mean ± SE LI of Ki67 antigen was significantly higher in primary adenoma and nodular hyperplasia than in normal parathyroid glands. CONCLUSION: These results indicate that downregulation of CaSR, and a higher rate of proliferation over apoptosis, could contribute to the pathological progression of SHPT.
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Authors | Hye-Jeong Lee, U-Hyoung Seo, Woo-Young Kim, Sang-Uk Woo, Jae-Bok Lee |
Journal | The Journal of international medical research
(J Int Med Res)
Vol. 41
Issue 1
Pg. 97-105
(Feb 2013)
ISSN: 1473-2300 [Electronic] England |
PMID | 23569134
(Publication Type: Journal Article)
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Chemical References |
- CASR protein, human
- Receptors, Calcium-Sensing
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Topics |
- Adenoma
(pathology)
- Adult
- Apoptosis
- Demography
- Humans
- Hyperparathyroidism, Secondary
(metabolism, pathology)
- Hyperplasia
- Immunohistochemistry
- In Situ Nick-End Labeling
- Middle Aged
- Parathyroid Glands
(metabolism, pathology)
- Receptors, Calcium-Sensing
(metabolism)
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