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Calcium-sensing receptor and apoptosis in parathyroid hyperplasia of patients with secondary hyperparathyroidism.

AbstractOBJECTIVE:
This retrospective study investigated the characteristics of secondary hyperparathyroidism (SHPT) by examining the presence of the calcium-sensing receptor (CaSR) and the rate of cell proliferation and apoptosis in parathyroid glands.
METHODS:
Eighteen diffuse and 57 nodular hyperplastic parathyroid glands from 24 patients with SHPT were compared with 14 primary adenomas and 33 normal parathyroid glands using immunohistochemical staining of CaSR and a marker of proliferative activity (Ki67 antigen). Apoptosis was measured using the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labelling assay.
RESULTS:
The mean ± SE labelling index (LI) of CaSR (12.8% ± 1.5%) in nodular hyperplasia was significantly lower than that in normal parathyroid glands (26.8% ± 0.8%), whereas the mean ± SE LI of CaSR in diffuse hyperplasia was similar to that in normal parathyroid glands (23.3% ± 1.8%). The mean ± SE LI of Ki67 antigen was significantly higher in primary adenoma and nodular hyperplasia than in normal parathyroid glands.
CONCLUSION:
These results indicate that downregulation of CaSR, and a higher rate of proliferation over apoptosis, could contribute to the pathological progression of SHPT.
AuthorsHye-Jeong Lee, U-Hyoung Seo, Woo-Young Kim, Sang-Uk Woo, Jae-Bok Lee
JournalThe Journal of international medical research (J Int Med Res) Vol. 41 Issue 1 Pg. 97-105 (Feb 2013) ISSN: 1473-2300 [Electronic] England
PMID23569134 (Publication Type: Journal Article)
Chemical References
  • CASR protein, human
  • Receptors, Calcium-Sensing
Topics
  • Adenoma (pathology)
  • Adult
  • Apoptosis
  • Demography
  • Humans
  • Hyperparathyroidism, Secondary (metabolism, pathology)
  • Hyperplasia
  • Immunohistochemistry
  • In Situ Nick-End Labeling
  • Middle Aged
  • Parathyroid Glands (metabolism, pathology)
  • Receptors, Calcium-Sensing (metabolism)

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