Abstract | INTRODUCTION: METHODS: Wistar rats were inoculated intravenously with the BOAS strain of P. brasiliensis and antifungal drugs were administered to the animals by gavage at the following doses (mg/kg weight/day): voriconazole (5 to 20), ketoconazole (12 to 15), fluconazole (6), itraconazole (4), and sulfamethoxazole- trimethoprim (120 to 150). The antifungal activity of the drugs was assessed by determining the P. brasiliensis colony forming units in the lungs and spleen of the animals at the end of treatment and by a survival study. RESULTS:
Voriconazole reduced the total tissue fungal burden of P. brasiliensis, particularly at doses of ≥ 10 mg/kg weight/day but its antifungal activity was less intense than that of fluconazole, itraconazole and sulfamethoxazole- trimethoprim. The mean survival of animals treated with the last three drugs, 29.1 ± 10.7, 26.1 ± 10.1 and 28.4 ± 9.6 days, respectively, was higher than that achieved with voriconazole 10mg/kg weight/day (18.5 ± 8.3 days) and that observed in untreated animals (15.7 ± 3.6 days). CONCLUSIONS:
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Authors | Daniela Silva Granzoto, Lúcia Helena Vitali, Roberto Martinez |
Journal | Revista da Sociedade Brasileira de Medicina Tropical
(Rev Soc Bras Med Trop)
2013 Jan-Feb
Vol. 46
Issue 1
Pg. 79-83
ISSN: 1678-9849 [Electronic] Brazil |
PMID | 23563830
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antifungal Agents
- Pyrimidines
- Triazoles
- Voriconazole
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Topics |
- Animals
- Antifungal Agents
(pharmacology)
- Disease Models, Animal
- Female
- Paracoccidioidomycosis
(drug therapy)
- Pyrimidines
(pharmacology)
- Rats
- Rats, Wistar
- Triazoles
(pharmacology)
- Voriconazole
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