Chemotherapy-induced takotsubo cardiomyopathy.

Abstract

Stress cardiomyopathy, also known as takotsubo cardiomyopathy, is a rapidly reversible form of acute heart failure classically triggered by stressful events. It is associated with a distinctive left ventricular contraction pattern described as apical akinesis/ballooning with hyperdynamic contraction of the basal segments in the absence of obstructive coronary artery disease. The traditional paradigm has expanded to include other causes, in particular chemotherapeutic drugs. The literature increasingly suggests an association between cancer, chemotherapeutic drugs, and stress cardiomyopathy. Chemotherapy-induced takotsubo cardiomyopathy is a relatively new phenomenon, but one that merits detailed attention to the elucidation of possible mechanistic links.

• Authors: Sakima A Smith, Alex J Auseon
• Journal: Heart failure clinics (Heart Fail Clin) Vol. 9 Issue 2 Pg. 233-42, x (Apr 2013) ISSN: 1551-7136 [Print] United States
• PMID: 23562124 (Publication Type: Case Reports, Journal Article, Review)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Chemical References

• Antibodies, Monoclonal, Murine-Derived
• Antimetabolites, Antineoplastic
• Antineoplastic Agents
• Rituximab
• Fluorouracil

Topics

• Antibodies, Monoclonal, Murine-Derived (adverse effects, therapeutic use)
• Antimetabolites, Antineoplastic (adverse effects)
• Antineoplastic Agents (adverse effects, therapeutic use)
• Echocardiography
• Electrocardiography
• Female
• Fluorouracil (adverse effects)
• Humans
• Lymphoma (drug therapy)
• Middle Aged
• Rituximab
• Stroke Volume (physiology)
• Takotsubo Cardiomyopathy (chemically induced, diagnosis, physiopathology)
• Ventricular Dysfunction, Left (chemically induced, diagnosis, physiopathology)