Exendin-4 attenuates ischemia-induced ventricular arrhythmias in rats.

Abstract

BACKGROUND:

Glucagon-like peptide-1 and its receptor agonist-exendin-4 (Ex-4) have been shown to provide beneficial effects for cardiovascular diseases. This study investigated the effects of Ex-4 on ischemia-induced ventricular arrhythmias in rats.

METHODS:

Anesthetized male rats were once treated with Ex-4 (5 μg/kg, i.v.) 1 h before ischemia in the absence and/or presence of 5-hydroxydecanoic acid (5-HD, 10 mg/kg, i.v., a specific inhibitor of mitochondrial ATP-sensitive potassium [KATP] channels) which were once injected 10 min before ischemia. And then subjected to ischemia for 30 min. Ventricular arrhythmias were assessed.

RESULTS:

During the 30-min ischemia, Ex-4 significantly reduced the incidence of ventricular fibrillation (VF) (p < 0.05). The duration of ventricular tachycardia (VT) + VF, the number of VT + VF episodes and the severity of arrhythmias were all significantly reduced by Ex-4 compared to those in myocardial ischemia group (p < 0.05 for all). Administration of 5-HD abolished the protective effects of Ex-4 on VF incidence, the duration of VT + VF, the number of VT + VF episodes and the severity of arrhythmias (p < 0.05 for all).

CONCLUSIONS:

This study suggested that Ex-4 could attenuate ischemia-induced ventricular arrhythmias in rats in which mitochondrial KATP channels may be involved.

• Authors: Zhang Kai, Wu Yongbo, Zhao Lin, Guo Jie, Jin Daoqun, Chen Zhiqiang
• Journal: Cardiology journal (Cardiol J) Vol. 20 Issue 1 Pg. 29-33 ( 2013) ISSN: 1898-018X [Electronic] Poland
• PMID: 23558808 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Arrhythmia Agents
• Decanoic Acids
• Hydroxy Acids
• Hypoglycemic Agents
• Peptides
• Potassium Channel Blockers
• Potassium Channels
• Venoms
• mitochondrial K(ATP) channel
• 5-hydroxydecanoic acid
• Exenatide

Topics

• Animals
• Anti-Arrhythmia Agents (pharmacology)
• Blood Pressure (drug effects)
• Decanoic Acids (pharmacology)
• Disease Models, Animal
• Exenatide
• Heart Rate (drug effects)
• Hydroxy Acids (pharmacology)
• Hypoglycemic Agents (pharmacology)
• Male
• Myocardial Ischemia (complications, drug therapy)
• Peptides (pharmacology)
• Potassium Channel Blockers (pharmacology)
• Potassium Channels (physiology)
• Rats
• Rats, Sprague-Dawley
• Tachycardia, Ventricular (drug therapy, etiology)
• Venoms (pharmacology)
• Ventricular Fibrillation (drug therapy, etiology)