Abstract | AIM: PATIENTS & METHODS: RESULTS: ABCA5/6/8/9/10, ABCB1/5/11, ABCC6/9, ABCD2/4, ABCG5 and ABCG8 were significantly downregulated and ABCA2/3/7/12, ABCB2/3/8/9/10, ABCC1/4/5/10/11/12, ABCD1/3, ABCE1, ABCF1/2/3 and ABCG1 were upregulated in post-treatment tumors compared with non-neoplastic tissues. Significant associations of intratumoral levels of ABCC1 and ABCC8 with grade and expression of hormonal receptors were found in both sets of patients. ABCA12, ABCA13 and ABCD2 levels were significantly associated with the response to neoadjuvant chemotherapy in post-treatment patients. Protein expression of ABCA12, ABCC8 and ABCD2 in tumor tissues of patients with breast carcinoma was observed by immunoblotting for the first time. CONCLUSION:
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Authors | Viktor Hlaváč, Veronika Brynychová, Radka Václavíková, Marie Ehrlichová, David Vrána, Václav Pecha, Renata Koževnikovová, Markéta Trnková, Jiří Gatěk, Dana Kopperová, Ivan Gut, Pavel Souček |
Journal | Pharmacogenomics
(Pharmacogenomics)
Vol. 14
Issue 5
Pg. 515-29
(Apr 2013)
ISSN: 1744-8042 [Electronic] England |
PMID | 23556449
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- ATP-Binding Cassette Transporters
- Antineoplastic Agents
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Topics |
- ATP-Binding Cassette Transporters
(genetics, metabolism)
- Antineoplastic Agents
(administration & dosage)
- Breast Neoplasms
(drug therapy, genetics, pathology)
- Carcinoma
(drug therapy, genetics, pathology)
- Female
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
- Genetic Association Studies
- Humans
- Middle Aged
- Neoadjuvant Therapy
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