Abstract | BACKGROUND: CASE PRESENTATION: A 35 year-old male with a 7-year history of Crohn's disease was treated with an ileocolonic resection and re-anastomosis followed by infliximab which maintained full endoscopic and clinical remission for four years. After stopping the infliximab for infusion-related reactions he presented with 3-day history of severe right eye pain, pain with ocular movement, proptosis, and conjunctival injection. He had no intestinal symptoms and endoscopic assessment revealed no active luminal disease. CT of the orbit revealed an enlarged right medial rectus muscle with tendonous involvement and a diagnosis of orbital myositis was made. Treatment with 80 mg per day prednisone with tapering dose and adalimumab, induction and maintenance, resulted in rapid resolution of the orbital myositis and ocular symptoms with no recurrences on follow-up at 10 months. CONCLUSIONS:
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Authors | Sanam Verma, Karen I Kroeker, Richard N Fedorak |
Journal | BMC gastroenterology
(BMC Gastroenterol)
Vol. 13
Pg. 59
(Apr 04 2013)
ISSN: 1471-230X [Electronic] England |
PMID | 23556424
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Humanized
- Infliximab
- Adalimumab
- Prednisone
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Topics |
- Adalimumab
- Adult
- Anti-Inflammatory Agents
(therapeutic use)
- Anti-Inflammatory Agents, Non-Steroidal
(therapeutic use)
- Antibodies, Monoclonal
(adverse effects)
- Antibodies, Monoclonal, Humanized
(therapeutic use)
- Crohn Disease
(complications, drug therapy)
- Humans
- Infliximab
- Male
- Orbital Myositis
(complications, drug therapy)
- Prednisone
(therapeutic use)
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